Postdoctoral Fellow- Oncology Discovery

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/.

The Post-doctoral Research Scientist-Oncology Discovery Hematological Malignancies [focused on Multiple Myeloma (MM)] will work independently on a project designed to further the understanding of MM and hematological malignancy biology with the goal of investigating mechanisms of T cell engager resistance. You will have the ability to work with and learn from experts within discovery oncology research, specialized in cell and molecular biology, flow cytometry, computational biology, and in vivo sciences, while also leveraging additional resources at J&J Innovative Medicine. The length of the position will be 2 years, the candidate is expected to present and publish their research.

• Work with discovery scientists within J&J Innovative Medicine to design and execute studies to further our understanding of mechanisms of resistance to T cell redirection therapeutics (ie. Bispecific/multispecific antibodies and CART), with a focus on the multiple myeloma (MM) disease area
• Integrate internal and external data in the design and interpretation of experiments
• Develop and utilize assays to mimic bone marrow-like conditions
• Investigate MM protein biology
• Use CRISPR/Cas9 screening technologies
• Design and analyze multi-color (6-16) flow cytometry experiments to characterize immune cell function (e.g., celesta, fortessa, symphony)
• Perform advanced molecular and cellular biology techniques (e.g., viral and non-viral cell transduction, Western blot, DNA/RNA isolation, and qRT-PCR)
• Perform functional T cell redirection assays using bispecific/multispecific antibodies and CART cell therapy
• Maintain detailed and organized experimental records and stay compliant on all relevant internal and external training requirements
• Communicate scientific results to multidisciplinary teams including computational biologists, bench scientists, clinicians, and management in an appropriate biological context

• A Ph.D. in cell and/or molecular biology, oncology, immunology, biochemistry, microbiology, or related field received in the last 0-3 years or by the start of this position.
• Expertise in the oncology area - including tumor biology, signaling, immuno-oncology, T cell redirection (antibody or cell therapy).
• MM biology and T cell engagement experience is preferred but not necessary
• Basic understanding of bioinformatics and/or RNA sequencing is preferred but not necessary
• Strong publication record demonstrating relevant experience
• Strong communication AND collaboration skills required with a One-Team focused approach
• Must be legally authorized to work in the U.S. for the full duration of the role

• Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.
• Employees may be eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)).
• This position is eligible to participate in the Company's long-term incentive program.
• Employees are eligible for the following time off benefits:
• Vacation - up to 120 hours per calendar year
• Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington - up to 56 hours per calendar year
• Holiday pay, including Floating Holidays - up to 13 days per calendar year
• Work, Personal and Family Time - up to 40 hours per calendar year