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City of Hope

Staff Scientist - Bioinformatics

Duarte, CA

About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

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Position Summary

The Bioinformatics Staff Scientist will work in a team environment in Andrea Bild's lab studying tumor heterogeneity using whole genome sequencing and single cell sequencing approaches, among others. The project will focus on our funded NIH Cancer Systems Biology Consortium ( ) program at City of Hope Comprehensive Cancer Center and provide exciting opportunities to engage with top scientists and cutting edge genomic research.

Key Responsibilities include:

For this position, the scientist will lead efforts to analyze high throughput sequencing data for detection of tumor heterogeneity and subclonal populaitons using WGS (for reference, please read: ), as well as subclonal phenotype and pathway activity using single cell sequencing data. S/he will manage the analysis and interpretation of genomics data from patient cohorts in order to understand why cancer progresses with resistant tumor clones that emerge during therapy. The successful candidate will also contribute to the development data workflow processes and pipelines. S/he will also have the opportunity to assist in training investigators and new users to use bioinformatics applications and databases.

Basic education, experience and skills required for consideration:
  • PhD degree in bioinformatics or equivalent and experience with NGS sequencing data lead research projects.
  • Demonstrated ability to solve biologically-relevant problems requiring novel applications of exploratory data analysis.
  • Ability to analyze data of high complexity by applying sound statistical and commonly accepted bioinformatics methods to -omics data with a collaborative project team.
  • Excellent English written and oral communication skills.
  • Excellence in scripting languages (phtyon, perl) and with R.
Preferred education experience and skills:
  • Knowledge of hardware including server.
Additional Information:
  • To protect the health of patients and staff and to comply with new State of California mandates, City of Hope staff are required to show proof of full vaccination by September 30, 2021. Compliance is a condition of employment.
City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

  • Posting Date: Nov 2, 2021
  • Job Field: Research
  • Employee Status: Regular
  • Shift: Day Job

Job ID: CityOfHope-10013747
Employment Type: Other