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City of Hope

Postdoctoral Fellow - Synthetic Chemist

Duarte, CA

Thank you for your interest. Please note, the purpose of this posting is to recruit for on-going and future positions.

About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

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Position Summary

A postdoctoral position is available for a synthetic chemist / synthetic biochemist to conduct research on novel bioactive derivatives of folic acid and on diagnostic assays for infectious diseases and bacterial toxins. Research will involve chemical and biological synthesis of compounds, microbiology, mass spectrometric methods and protein biochemistry. A preferred candidate should be experienced in synthetic biochemistry or chemistry, microbiology, and molecular biology. Additional knowledge in the fields of immunology, metabolism, and cutting-edge analytical methods is preferred. The trainee will benefit from a close interaction with world-class clinical and basic science faculty and staff, and gain experience in state-of-the-art proteomics, molecular genetics, cell biology, and animal model experimentation.

Please submit a CV with Cover Letter and the names of 3 references with your application.

Key Responsibilities:
  • Chemical or microbiological synthesis of novel folic acid derivatives.
  • Exploration of the metabolic effects of such novel folic acids in biological systems.
  • Design, synthesis, and testing of novel substrate molecules for the sensitive detection of proteases in biological matrices.
  • Development and application of targeted mass spectrometric techniques.
  • Application and design of molecular biology approaches, including molecular cloning, expression, and purification of recombinant proteins
  • Swift publication of results in peer reviewed manuscripts and mandatory progress reports.
Basic education, experience and skills required for consideration:
  • Ph.D. and/or M.D. degree in life or biomedical sciences or a related discipline is required.
Additional Information:
  • For more information on Dr. Markus Kalkum's research please visit here
  • To protect the health of patients and staff and to comply with new State of California mandates, City of Hope staff are required to show proof of full vaccination by September 30, 2021. Compliance is a condition of employment.
City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.


  • Posting Date: Nov 26, 2021
  • Job Field: Research
  • Employee Status: Regular
  • Shift: Day Job

Job ID: CityOfHope-10013880
Employment Type: Other