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City of Hope

Post-doctoral Fellow - Immuno-oncology

Duarte, CA

About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

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Position Summary:

A Postdoctoral Fellow position is available in the laboratory of Dr. Heather McGee, MD, PhD, Assistant Professor in the Departments of Radiation Oncology and Immuno-oncology in the Beckman Research Institute at City of Hope. The post-doctoral researcher must be interested in tumor immunology and the immune response to radiation in multiple cancer types, including hepatocellular carcinoma, colorectal cancer, pancreatic cancer and lung cancer. Research in the McGee lab spans the entire spectrum from cell culture experiments with cancer cell lines, to murine experiments with transgenic mouse models and knock-in reporter mice, to imaging studies with patient samples. The post-doctoral fellow will utilize techniques including murine irradiation, multicolor flow cytometry, multi-plex immunofluorescence, microscopy, and scRNA sequencing to dissect biologic mechanisms activated by radiation that influence the local immune response in various tumor microenvironments. The post-doctoral fellow will play a leading role in NIH-funded research and have the opportunity to be first author on multiple presentations and publications that stem from this work.

Dr. McGee is looking for a post-doctoral fellow who is eager to be challenged scientifically, hone his/her critical thinking skills and test new hypotheses in creative ways. Dr. McGee emphasizes mentorship and plans to work closely with all members of the lab to ensure that they feel like valued members of the team. Dr. McGee is eager to mentor post-doctoral fellows of all backgrounds who want to go on to develop a productive career in academic medicine or science and will provide career opportunities to help the post-doctoral fellow achieve his or her career goals.

The long-term goals of the McGee lab are to identify key molecular and immunologic pathways that can be targeted to enhance the immune response to radiation and develop personalized medicine approaches for cancer patients treated with radiation. The post-doctoral researcher will play a key role in all steps of this process with the potential to apply their pre-clinical research findings to patients in a future translational study.

Basic education, experience and skills required for consideration:
  • A Ph.D. degree in immunology, cancer biology or a related discipline is required with at least 1 first author publication.
  • Experience in cellular immunology is required.
  • Proficiency with murine tumor models and multicolor flow cytometry is required.
  • A desire to work in a collaborative, interdisciplinary lab environment that values creativity, initiative, hard work, professionalism, and teamwork is required.
Additional Information:
  • Dr. McGee's research is supported by an NIH/ NCI R00 grant from the National Cancer Institute and a generous start-up package from City of Hope.
  • Research findings from Dr. McGee and colleagues have been published in Nature , Nature Communications , Clinical Cancer Research , Journal of Immunology , Journal for Immunotherapy of Cancer , International Journal of Radiation Oncology Biology and Physics , and numerous other journals.
  • To protect the health of patients and staff and to comply with new State of California mandates, City of Hope staff are required to show proof of full vaccination by September 30, 2021. Compliance is a condition of employment.
City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

  • Posting Date: Nov 19, 2021
  • Job Field: Clinical Research
  • Employee Status: Regular
  • Shift: Day Job

Job ID: CityOfHope-10014296
Employment Type: Other