Quanterix is a company that is digitizing biomarker analysis with the goal of advancing the science of precision health. The company's ultra-sensitive detection solution, Simoa, has the potential to change the way in which healthcare is provided today by giving researchers the ability to closely examine the role of biomarkers in the continuum of health to disease. Quanterix' technology is designed to enable much earlier disease detection, better prognosis and precise treatment methods to improve the quality of life and longevity of the population for generations to come. The technology is currently being used for research applications in several therapeutic areas, including oncology, neurology, cardiology, inflammation and infectious disease.
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We are looking for an experienced and highly motivated Research Associate, Tissue Diagnostics experienced in conventional immunohistochemistry and antibody validation in FFPE tissue sections. Knowledge of immunofluorescence, imaging of brightfield/fluorescent slides and digital image analysis are a plus but nor required. Additional knowledge of biomarkers in the oncology/immune-oncology space is preferred. The successful candidate will be actively involved in development, automation, and standardization of multiplexed immunofluorescent assays on FFPE tissue, and imaging thereof.
The service lab will provide fee-based services to pharma and biotech clients, help them understand trial results, in particular as results relate to data provided by Quanterix' Simoa blood protein platform. Candidates should be interested in biomarker science and translational pathology, well versed in laboratory techniques such as immunohistochemistry (IHC), immunofluorescence (IF) and microscopy. This person will report to the Principal Scientist, Tissue Diagnostics Lab Services or to the Senior Director, Tissue Diagnostics Lab Services at Quanterix.
What You'll Do:
- Testing, optimization, and validation of antibodies on FFPE tissue sections.
- Identification of available antibodies for new targets of interest, preparation of background presentations on target biology, antibody performance and expected staining patterns.
- Imaging and review of stained sections; quantitative QC of run controls.
- Acceptance testing of reagents and materials.
- Processing (staining and imaging) of client samples.
- General laboratory maintenance including maintenance of equipment, inventory management, ordering of supplies, reagent preparation, documentation thereof. All equipment, instruments, and accessories must be operational, and irregularities are reported in compliance with Quanterix Quality System.
- Supporting sample and inventory tracking/management.
- Working with senior members of the team to design and carry out experiments, interpret and present data. Presentation of findings to the team internally.
- Contributing to the development and update of Standard Operating Procedures (SOPs) and Work Instructions (WIs).
- Sectioning of FFPE tissue blocks (if experienced and trained as a Histotechnologist).
What We'll Expect From You:
- Bachelor's degree in Life Sciences or related fields.
- Relevant professional experience (at least 2+ years) in a laboratory/pathology environment.
- Experience with antibody optimization/validation, titration techniques, and general laboratory practices.
- Experience with IHC, processing of FFPE tissue samples, automated staining systems, pathology workflows.
- Experience with sectioning of FFPE tissue; HT/HTL certification desirable but not required.
- Experience with fluorescence immunohistochemistry, imaging, and image analysis are a plus but not required.
- Work experience in a laboratory/analytical setting compliant with CLIA and GCP regulations.
- Detail oriented and organized.
- Ability to prioritize and work in a fast-paced team environment, ability to work independently and as a team member.
- Demonstrated competence in research techniques and methodologies.
- Good computer skills including Microsoft Word, Excel, and PowerPoint; experience with tracking/LIM systems, electronic laboratory notebooks, document management systems.
- Histotechnology certification is a plus but not required.
- Passion for pathology and personalized medicine.
Why You'll Like Working For Us:
Our Technology: Quanterix' technology is designed to enable much earlier disease detection, better prognoses and enhanced treatment methods to improve the quality of life and longevity of the population for generations to come. The technology is currently being used for research applications in several therapeutic areas. The company was established in 2007 and is in Billerica, Massachusetts. For additional Information, please visit https://www.quanterix.com.
Our Commitment to Employees: At Quanterix, we take pride in our employees' incredible work ethic, and we want to reward and recognize that by offering competitive compensation and a 401k plan with an employer match, as well as competitive health, dental, and vision benefits for employees and their dependents. We also offer an unlimited vacation policy to all exempt employees, and a generous PTO policy for non-exempt employees. All employees are awarded Equity, and we have an Employee Stock Purchase Plan, a Performance Bonus, and 1:1 Financial Counseling/Planning. We also offer Tuition Assistance. We have a free, state-of-the-art onsite fitness center for all employees. To keep you fueled up, we provide onsite employees free snacks and drinks every day!
Quanterix is committed to a Diverse and Inclusive workplace. Quanterix is an Equal Opportunity Employer and does not discriminate based on race, national origin, gender, gender identity, sexual orientation, protected veteran status, disability, age, or other legally protected status. Quanterix will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
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