LC-MS Chemist - Metabolism

Labcorp is seeking an LC-MS Chemist - Metabolism to join our team in Madison, WI.

Work Schedule: Monday - Friday 8:00 am - 5:00 pm

Job Responsibilities

• Organize and independently perform routine to moderate-level method validation activities in compliance with SOPs and regulatory guidelines (GLP/GCP).
• Execute advanced method validation tasks with guidance from a Lead Scientist.
• Apply intermediate data interpretation and analytical instrumentation skills to resolve procedural and scientific problems with minimal assistance.
• Assist in the review of reports, methods, protocols, and SOPs; maintain complete and audit-ready study documentation.
• Communicate problems, deviations, and corrective actions to Lead Scientist and/or management in a timely manner.
• Manage assigned project work, coordinating activities with team members to deliver high-quality data to internal clients on schedule.
• Collaborate effectively with colleagues across the Bioanalytical site and support cross-functional communications with external clients.
• Train and mentor less experienced laboratory staff.
• Contribute to process improvement initiatives and participate in department-wide quality initiatives.
• Maintain a clean, safe, and organized laboratory environment.

• Bachelor's degree, MS, PhD in Life Sciences, Chemistry, Biotechnology, or a related field.
• 2 or more years hands-on experience with LC-MS/MS bioanalysis, including MRM-based quantitation and method execution.
• 2 or more years of experience with ADME/PK assays such as liver microsomal stability, permeability assays (e.g., MDCK-MDR1), and PK sample processing (plasma, tissue lysates).
• 2 or more years operating triple quadrupole mass spectrometer platforms (e.g., Waters Xevo TQS, Agilent 6400 QQQ, SCIEX 5500, and SCIEX 6500).

• 1 or more years of exposure to CYP inhibition or Time-Dependent Inhibition (TDI) assays and drug-drug interaction (DDI) studies.
• 1 or more years of experience assisting in the development or optimization of new bioanalytical methods.
• Master's degree or other post graduate studies in a relevant life sciences discipline.

• Proficiency with data acquisition and processing software (MassLynx, MassHunter, Analyst, or equivalent).
• Proficiency with ELN documentation, word processing, spreadsheet, and specialized analytical software.
• Strong attention to detail with demonstrated ability to generate reproducible, high-quality bioanalytical data.
• Familiarity with Orbitrap platforms or other high-resolution mass spectrometry systems.
• Knowledge of regulatory guidelines including FDA, EMA, and ICH bioanalytical method validation guidance.
• Experience working in a GLP/GCP-regulated environment (CRO or pharmaceutical/biotech industry).
• Excellent written and verbal communication skills.
• Proven ability to prioritize workloads and manage time effectively in a fast-paced laboratory environment.