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City of Hope

Research Associate II - Leo Wang Lab

Duarte, CA

About City of Hope:

City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's 20 leading cancer centers that develops and institutes standards of care for cancer treatment.

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Position Summary:

Under general supervision of the Principal Investigator, or designee, the Research Associate II (RAII) directs the work of a laboratory or undertakes research projects in collaboration with academic supervisor, making innovative contributions pertaining to laboratory procedures which may not change the course of an investigation but do indicate significant independent contribution beyond the RA I level. RAII typically consults with the academic supervisor on the scope and plan of approach to a research project; reads abstracts and articles; organize and plan techniques; plan and assign the work of at least one lab staff advising on problems they are unable to solve; contribute original ideas to the laboratory research; standardize new techniques and train staff on these techniques; perform specialized procedures and prepare written reports of laboratory experimental methods.

A Research Associate II position is available in the laboratory of Leo D. Wang, MD, PhD, at City of Hope, Duarte, CA.

The lab's research in the Department of Immuno-Oncology focuses on how blood and immune cells develop, function, and interact with other cells, with a second focus on how blood stem cells become malignant. We use mass spectrometry to identify activated protein circuits in rare blood stem and progenitor cell populations, including therapeutic chimeric antigen receptor (CAR) T cells, and use that knowledge to improve and devise new therapies for pediatric cancers and blood disorders.

To learn more about our research, visit or

Principal Duties and Responsibilities:
  • Coordinate lab tasks and operations, including ordering, inventory, and other essential functions.
  • Prepare laboratory reagents, chemicals, instruments, and maintain equipment.
  • Performs a variety of routine and non-routine laboratory research experiments. Records and validates results and methodology for accuracy and completeness.
  • Perform preclinical rodent work (mouse handling, screening, injections, and analysis). Troubleshoots procedures if experiment results are unexpected or unsatisfactory. Recommends alternative procedures.
  • Calculates, compiles and analyzes data obtained from work performed.
  • Independently evaluates research data and initiates alternative approaches to improve the quality of results by providing input to overall research design. Trains lab staff in specialized procedures, equipment and theoretical concepts behind unique tests.
  • Keep detailed and accurate logs of experiments from conception to analysis, as well as of lab inventory and animal colonies.
  • May contribute to the preparation of manuscripts by describing methods and specialized techniques.
  • There may be some travel to local area research labs for collaborations, trainings, & operational expansion.
Basic Education, Experience and Skills required for consideration:
  • B.A/B.S with significant biological science coursework required.
  • Hands-on experience with flow cytometry, molecular biology, and cell culture is preferred.
  • Computational skills (R, Python) are beneficial.
  • Experience with animal husbandry also a plus.
  • Two years related research/ laboratory experience with a Bachelor's degree or
  • One year related research/ laboratory experience with a Master's degree

Preferred Education, Experience and Skills:
  • Master's degree.

Ideal candidates will be self-motivated and have ambitions to further develop their scientific and career skills. They will have a desire to be challenged and to learn new scientific strategies.

In addition to competitive compensation and benefits, candidates will have the opportunity to learn and to develop research publications and presentations. Particularly effective candidates may be given the opportunity to develop an independent project.

Must be able to work meticulously, develop cohesive team relationships, communicate effectively in English, respond to and improve based on constructive feedback, and show dedication and commitment to our science.

Candidates will receive training in the safe handling of toxic chemicals, biohazards, animals, and other reagents. Candidates may also occasionally work with radiation.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability. #LI-GD

  • Posting Date: Jun 22, 2021
  • Job Field: Research
  • Employee Status: Regular
  • Shift: Day Job

Job ID: CityOfHope-10011164-3
Employment Type: Other