Sr. Scientist, Biologics Protein Biochemistry

About This Role

The Biologics Protein Biochemistry group at Biogen seeks an experienced and highly motivated scientist to contribute to our mission of developing medicines that transform patients' lives. The successful candidate will play a key role in designing, generating, and characterizing antibody-based therapeutics, including bispecifics and novel fusion proteins. This position requires strong technical expertise in protein purification and characterization and will involve a balance of hands-on lab work and management of external protein production efforts at Contract Research Organizations (CROs). The individual will collaborate closely with teams across Research to support candidate selection and lead optimization efforts that advance our therapeutic pipeline.

What You'll Do

• Develop and optimize protein purification schemes for engineered antibodies using computer-interfaced chromatography systems (e.g., AKTA or similar) utilizing a various chromatographic techniques
• Characterize proteins using biophysical and analytical methods including SEC-MALS, DLS, SDS-PAGE, and analytical SEC
• Contribute to the design and engineering of bispecific antibodies and novel fusion proteins to achieve desired activity, binding specificity, and manufacturability
• Manage all aspects of protein production activities at CRO
• Actively contribute to project strategy and experimental design, and regularly present findings at team meetings
• Document experimental work clearly and completely in electronic lab notebooks and technical reports

Who You Are

You're a hands-on protein biochemist with deep expertise in purification and biophysical characterization. In addition to performing benchwork yourself, you have experience overseeing protein production at CROs and bring strong operational and organizational skills to the table. You thrive in a collaborative, fast-paced environment and are known for your clear communication and attention to detail.

Required Skills

• Ph.D. in biochemistry or a related field with 2-4 years industry experience, or a Master's degree with 4+ years relevant industry experience.
• Extensive experience in protein purification, including method development across multiple chromatographic techniques (IEX, HIC, affinity)
• Proficiency with automated purification systems (e.g., ÄKTA)
• Strong analytical and biophysical skills, including DLS, SEC-MALS, SDS-PAGE, and SEC
• Experience designing antibody-based formats such as bispecifics and fusion proteins
• Track record of managing CRO relationships and external protein production
• Strong organizational skills and attention to detail
• Excellent communication and data presentation skills

Preferred Skills

• Experience designing protein expression constructs at the DNA level
• Experience with bioconjugation

Job Level: Management

Additional Information

The base compensation range for this role is: $122,000.00-$163,000.00

Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.

Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.

In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees' and their families physical, financial, emotional, and social well-being; including, but not limited to:

• Medical, Dental, Vision, & Life insurances
• Fitness & Wellness programs including a fitness reimbursement
• Short- and Long-Term Disability insurance
• A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
• Up to 12 company paid holidays + 3 paid days off for Personal Significance
• 80 hours of sick time per calendar year
• Paid Maternity and Parental Leave benefit
• 401(k) program participation with company matched contributions
• Employee stock purchase plan
• Tuition reimbursement of up to $10,000 per calendar year
• Employee Resource Groups participation

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.

Client-provided location(s): Cambridge, MA

Job ID: Biogen-REQ21426

Employment Type: FULL_TIME

Posted: 2025-09-02T23:59:49