Director, Variant Analysis - Invitae

Invitae, part of Labcorp, is seeking a Director, Variant Analysis to play a key role in advancing clinical variant interpretation and reporting across its product portfolio. This leader will provide strategic direction for the growth and scaling of clinical reporting operations, serving as a trusted voice for clinical operations in cross-company initiatives. The role brings deep expertise in clinical reporting workflows, team development, and process optimization to support high-quality, scalable operations. This is a Director-level position with leadership accountability, though it does not presently include direct people-management responsibilities. Over time, the role is expected to transition into a formal people-lead position.

Please note: this position has the option to be 100% remote in the US, or physically located at our laboratory in San Francisco, CA.

• Provide strategic, technical, and operational leadership for clinical interpretation and reporting activities across core technologies including whole genome sequencing (WGS), whole exome sequencing (WES), targeted NGS panels, and chromosomal microarray (CMA)
• Serve as a subject matter expert in genomic testing workflows, interpretation frameworks, and clinical reporting standards, ensuring scientific rigor, clinical relevance, and regulatory compliance
• Oversee day-to-day operational performance, including production scheduling, capacity planning, process health monitoring, and escalation of operational incidents
• Establish, optimize, and scale end-to-end workflows for clinical interpretation and reporting, applying continuous improvement methodologies to improve efficiency, quality, and throughput
• Define, implement, and monitor key operational metrics to assess performance, identify risk, and communicate status, trends, and opportunities to senior leadership
• Ensure delivery of high-quality clinical reports that meet established turnaround time, accuracy, and quality benchmarks
• Lead diagnosis and resolution of complex production issues, driving root-cause analysis and implementation of sustainable corrective and preventive actions
• Develop and execute operational strategies and goals aligned with broader organizational objectives and key results
• Act as an individual-contributor Director with significant strategic and operational scope, with the expectation of evolving people leadership responsibilities as the organization scales
• Mentor and coach scientists, genetic counselors, and operational partners, fostering a culture of continuous learning, accountability, and scientific excellence
• Collaborate cross-functionally with Laboratory, Bioinformatics, Product, Quality, Regulatory, IT, and Clinical Development teams to support successful launch of new assays, tools, and initiatives
• Provide input into strategic planning, organizational design, and capacity modeling through data-driven insights
• Foster a culture of operational excellence, best practices, and professional growth
• Perform other duties as assigned in support of departmental and company goals

• PhD in Biological Sciences, Molecular Genetics, Human Genetics, or a related field, with a minimum of 5 years of related work experience; or
• Master's degree in Genetic Counseling, Biological Sciences, Molecular Genetics, Human Genetics, or a related field, with a minimum of 6 years of related work experience; or
• Bachelor's degree in Genetics, Biological Sciences, Molecular Genetics, Human Genetics, or a related field, with a minimum of 7 years of related work experience

• Clinical genomics or molecular diagnostics experience in a CLIA-certified or similarly regulated laboratory environment
• Variant interpretation, curation, and clinical reporting for NGS-based assays, including WGS, WES, and/or targeted panels
• Operational leadership supporting clinical interpretation or reporting workflows, including capacity planning, quality management, and process optimization
• Cross-functional collaboration with laboratory, bioinformatics, product, quality, regulatory, or clinical development teams
• Experience supporting the development, launch, or scaling of clinical genomic assays or interpretation programs
• Minimum of 5 years of experience in operational leadership, including workflow optimization, capacity planning, performance metrics, and cross-functional execution
• Demonstrated ability to independently lead complex initiatives and influence outcomes without direct people management responsibility
• Strong understanding of clinical reporting operations, quality systems, and regulated laboratory environments (e.g., CLIA, CAP)
• Proven ability to operate at a Director level, balancing strategic planning with hands-on operational leadership
• Strong analytical, problem-solving, and communication skills, with the ability to translate technical and operational data into executive-level insights
• Demonstrated technical expertise with whole genome sequencing (WGS) and whole exome sequencing (WES), including strong understanding of clinical interpretation frameworks, reporting standards, and end-to-end workflows
• Knowledge of advanced copy number detection methodologies and copy number variant (CNV) interpretation across CMA and NGS-based platforms

• Lean Six Sigma certification (Green Belt or higher) or demonstrated experience applying Lean, Six Sigma, or similar continuous improvement methodologies in a scaled operational environment
• Director-level experience within a CLIA-certified diagnostic laboratory or similarly regulated clinical setting
• Deep familiarity with next-generation sequencing technologies and clinical interpretation frameworks, including variant curation and assessment of clinical relevance
• Knowledge of advanced copy number detection methodologies and copy number variant (CNV) interpretation across CMA and NGS-based platforms
• Experience with rapid or NICU whole genome sequencing (NICU WGS), including high-acuity clinical workflows, expedited turnaround requirements, and cross-functional coordination
• Experience or strong interest in one or more clinical domains, including oncology, cardiology, neurology, carrier screening, metabolic disorders, pediatric diagnostics, cytogenomics, and/or exome analysis
• Demonstrated experience scaling clinical interpretation or reporting operations in a high-throughput, regulated environment

• Excellent written, verbal, and interpersonal communication skills
• Ability to follow standard operating procedures with accuracy and attention to detail
• Ability to adapt to significant change that is inherent in development and innovation
• Desire to work in and contribute to a fast-paced, highly collaborative environment
• Demonstrated ability to understand, synthesize, and coherently evaluate complex genetic information.
• A sense of curiosity, strong collaborative spirit, and a willingness to learn