Director, Clinical Genomics Operations & Variant Science - Invitae - Remote

Labcorp is seeking a US remote-based Director of Clinical Genomics Operations & Variant Science to join its Invitae Genetics division!

Responsibilities:

• Provide strategic, technical, and operational leadership for clinical interpretation and reporting across WGS, WES, targeted NGS panels, and chromosomal microarray (CMA)
• Serve as subject matter expert in genomic testing workflows, interpretation frameworks, and clinical reporting standards - ensuring scientific rigor, clinical relevance, and regulatory compliance
• Oversee day-to-day operational performance including production scheduling, capacity planning, process health monitoring, and escalation of operational incidents
• Establish, optimize, and scale end-to-end workflows for clinical interpretation and reporting using continuous improvement methodologies
• Define, implement, and monitor key operational metrics to assess performance, identify risk, and communicate trends to senior leadership
• Ensure delivery of high-quality clinical reports meeting established turnaround time, accuracy, and quality benchmarks
• Lead root-cause analysis and implementation of corrective and preventive actions for complex production issues
• Develop and execute operational strategies aligned with broader organizational OKRs
• Mentor and coach scientists, genetic counselors, and operational partners - fostering a culture of continuous learning and scientific excellence
• Collaborate cross-functionally with Laboratory, Bioinformatics, Product, Quality, Regulatory, IT, and Clinical Development to support launch of new assays, tools, and initiatives
• Act as an individual-contributor Director with expectation of transitioning to formal people management within ~6 months

Minimum Qualifications:

• PhD in Biological Sciences, Molecular Genetics, or Human Genetics with 5 years or more of related work experience; OR Master's degree in Genetic Counseling, Biological Sciences, Molecular Genetics, or Human Genetics with 6 years or more of related work experience; OR Bachelor's degree in Genetics, Biological Sciences, Molecular Genetics, or Human Genetics with 7 years or more of related work experience
• 3 years or more of demonstrated expertise in variant interpretation, curation, and clinical reporting for NGS-based assays, including WGS and WES and/or targeted panels. This includes current or previous hands-on variant interpretation experience
• 3 years or more of experience driving operational efficiency and scaling production workflows supporting clinical interpretation and/or reporting
• 3 years or more experience of demonstrated ability to coach, develop, and elevate operational or production teams, with strong organizational and execution skills
• 3 years or more of experience managing or influencing complex initiatives with measurable outcomes in a high-throughput setting
• 5 years or more of experience in operational leadership, including managing a team, workflow optimization, capacity planning, performance metrics, and cross-functional execution

Preferred Qualifications:

• 5 years or more of Director-level experience within a CLIA-certified diagnostic laboratory or similarly regulated clinical setting
• 3 years or more of experience developing, launching, or scaling clinical genomic assays or interpretation programs
• 2 years or more of experience with rapid or NICU whole genome sequencing (NICU WGS) and high-acuity clinical workflows
• 2 years or more of familiarity with copy number variant (CNV) detection and interpretation across CMA and NGS-based platforms
• Lean Six Sigma (Green Belt or higher) certification or equivalent continuous improvement experience
• 3 years or more of experience scaling high-throughput clinical interpretation/reporting operations

Additional Job Standards:

• Background or interest in clinical domains such as oncology, cardiology, neurology, carrier screening, metabolic disorders, pediatrics, or cytogenomics

• Operational leadership supporting clinical interpretation or reporting workflows, including capacity planning, quality management, and process optimization
• Cross-functional collaboration with laboratory, bioinformatics, product, quality, regulatory, or clinical development teams
• Experience supporting the development, launch, or scaling of clinical genomic assays or interpretation programs
• Demonstrated ability to independently lead complex initiatives and influence outcomes without direct people management responsibility
• Strong understanding of clinical reporting operations, quality systems, and regulated laboratory environments (e.g., CLIA, CAP)
• Proven ability to operate at a Director level, balancing strategic planning with hands-on operational leadership
• Strong analytical, problem-solving, and communication skills, with the ability to translate technical and operational data into executive-level insights
• Demonstrated technical expertise with whole genome sequencing (WGS) and whole exome sequencing (WES), including strong understanding of clinical interpretation frameworks, reporting standards, and end-to-end workflows
• Excellent written, verbal, and interpersonal communication skills
• Ability to adapt to significant change that is inherent in development and

This is a Director-level role with leadership accountability and strong operational ownership. While initially an individual contributor role, it is expected to transition into formal people management within approximately 6 months.

Application Window Closes: 5/1/2026

**Salary Range: $125,000 - $225,000/ year

All job offers will be based on a candidate's skills and prior relevant experience, applicable degrees/certifications, as well as internal equity and market data.

The position is also eligible for an annual bonus under the Labcorp Bonus Plan. Bonuses are payable based on corporate and/or business segment performance and are subject to individual performance modifiers.

Benefits: Employees regularly scheduled to work 20 or more hours per week are eligible for comprehensive benefits including: Medical, Dental, Vision, Life, STD/LTD, 401(k), Paid Time Off (PTO) or Flexible Time Off (FTO), Tuition Reimbursement and Employee Stock Purchase Plan. Employees regularly scheduled to work less than 20 hours, Casual, Intern, and Temporary employees are only eligible to participate in the 401(k) Plan. Employees who are regularly scheduled to work a 7 on/7 off schedule are eligible to receive all the foregoing benefits except PTO or FTO. For more detailed information, please click here.

Labcorp is proud to be an Equal Opportunity Employer:

Labcorp strives for inclusion and belonging in the workforce and does not tolerate harassment or discrimination of any kind. We make employment decisions based on the needs of our business and the qualifications and merit of the individual. Qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex (including pregnancy, childbirth, or related medical conditions), family or parental status, marital, civil union or domestic partnership status, sexual orientation, gender identity, gender expression, personal appearance, age, veteran status, disability, genetic information, or any other legally protected characteristic. Additionally, all qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable law.

We encourage all to apply

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Client-provided location(s): San Francisco, CA

Job ID: labcorp-2613147_1372487102

Employment Type: OTHER

Posted: 2026-04-25T00:01:56