Principal UI Engineer

At Cadence, we hire and develop leaders and innovators who want to make an impact on the world of technology.

Scientists around the world use Orion for early-stage drug discovery and design in the pursuit of improving human health. Orion combines the power of advanced HPC, computational methods, and in-browser 3D visualization & modeling to solve problems in drug discovery & design. Our innovative solutions enable customers to routinely model billions of compounds in-silico. Orion enables our customers to interactively explore chemical space, evaluate designs and gain scientific understanding.

As a Principal UI Engineer, you will work with designers, scientists, and software engineers to enhance & extend Orion's UI capabilities. You'll have the chance to work on a multitude of interesting challenges across scientific visualization, collaboration, data management, as well as new product & feature development. You'll be part of a team building cutting edge features, as well as helping to modernize existing software.

Minimum Qualifications:

• BS in computer science/engineering, biology/chemistry or similar with a minimum of 7 years of experience OR MS with a minimum of 5 years of experience OR PhD with a minimum of 1 year of experience
• Experience designing, developing, troubleshooting and debugging complex user interfaces and software systems as part of a team
• Expert in JavaScript/Typescript/CSS/HTML
• Experience with Vue, Pinia/VueX and application frameworks such as Nuxt.js / Next.js.
• Experience in Life Sciences, HPC, Python, AWS, Web Workers, WebAssembly, and WebGL are a plus
• Experience with unit & end-to-end testing, CI/CD, source control, code review, comfortable using command line interfaces
• Strong background of computer science fundamentals (data structures, algorithms)
• Passionate to learn and explore new technologies and demonstrates good analysis and problem-solving skills

Interpersonal skills required:

• Ability to establish a close working relationship with peers in development, science, design and customer success, often across time zones
• Take initiative to solve unexpected challenges during development
• Willing to expand their knowledge and skills in both technical and scientific areas
• Push to raise the bar while always operating with integrity

OpenEye, Cadence Molecular Sciences, an industry leader in computational molecular design, uses a scientific approach to deliver rapid, robust, and scalable software, toolkits, and technology & design services for the advancement of pharmaceuticals, biologics, agrochemicals, and flavors

The annual salary range for Massachusetts is $117,600 to $218,400. You may also be eligible to receive incentive compensation: bonus, equity, and benefits. Sales positions generally offer a competitive On Target Earnings (OTE) incentive compensation structure. Please note that the salary range is a guideline and compensation may vary based on factors such as qualifications, skill level, competencies and work location. Our benefits programs include: paid vacation and paid holidays, 401(k) plan with employer match, employee stock purchase plan, a variety of medical, dental and vision plan options, and more.

We're doing work that matters. Help us solve what others can't.

Client-provided location(s): Boston, MA

Job ID: Cadence-R51440

Employment Type: FULL_TIME

Posted: 2025-10-01T18:37:58