Sr. Scientist, Biomarker Discovery

About This Role:

As a Sr. Scientist in Biomarker Discovery, you will play a pivotal role in advancing immunology therapeutics within our organization. Working with the WCH team, you will lead and execute cutting-edge biomarker research across non-clinical and clinical stages. Your expertise will be crucial in generating high-quality biomarker data from non-human primate and human samples, focusing on mechanism of action, target engagement, and immune pathway modulation. This position requires a strong hands-on approach to experimental work, particularly in flow cytometry-based assays, while collaborating closely with clinical and translational partners. Your contributions will be essential in bridging immune biology with clinical development, providing decision-enabling insights that drive clinical strategies and therapeutic advancements.

What You'll Do:

• Lead and execute clinical and translational biomarker research to establish mechanism of action, target engagement, and immune pathway modulation for clinical-stage immunology therapeutics.

• Independently design, perform, analyze, and interpret experiments using primary human samples to generate robust, decision-enabling biomarker data.

• Develop, optimize, and own multiparameter flow cytometry-based clinical biomarker assays, including immune phenotyping, receptor occupancy, and pharmacodynamic readouts.

• Support assay qualification, method transfer to CROs, and longitudinal clinical biomarker data review, ensuring assay robustness and interpretability.

• Communicate biomarker insights clearly to cross-functional stakeholders to influence clinical strategy, study interpretation, development decision, and scientific narrative.

Who You Are:

You are an innovative thinker with a passion for immunology and biomarker research. Your meticulous attention to detail and analytical mindset enables you to design and interpret complex experiments. You thrive in collaborative environments, where your ability to communicate complex scientific concepts clearly to various stakeholders makes you an invaluable team member. Your dedication to advancing clinical-stage therapeutics is driven by a desire to impact patient care positively.

Required Skills:

• PhD in Immunology or related biomedical science field (Bachelors or Masters with additional directly relevant experience may be considered).

• 2+ years of relevant industry or translational research experience supporting clinical-stage immunology programs (6+ years with MS, 8+ years with BS).

• Expertise in flow cytometry based assays and biomarker development.

• Strong analytical and experimental skills in immunology research.

• Excellent communication skills to convey scientific insights effectively.

Preferred Skills:

• Experience in assay qualification and method transfer to CROs.

• Proficiency in immune phenotyping, receptor occupancy, and pharmacodynamic readouts.

• Familiarity with clinical biomarker data review and interpretation.

Job Level: Management

Additional Information

The base compensation range for this role is: $123,000.00-$164,000.00

Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.

Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.

In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees' and their families physical, financial, emotional, and social well-being; including, but not limited to:

• Medical, Dental, Vision, & Life insurances
• Fitness & Wellness programs including a fitness reimbursement
• Short- and Long-Term Disability insurance
• A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
• Up to 12 company paid holidays + 3 paid days off for Personal Significance
• 80 hours of sick time per calendar year
• Paid Maternity and Parental Leave benefit
• 401(k) program participation with company matched contributions
• Employee stock purchase plan
• Tuition reimbursement of up to $10,000 per calendar year
• Employee Resource Groups participation

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.

Client-provided location(s): San Francisco, CA

Job ID: Biogen-REQ23423

Employment Type: FULL_TIME

Posted: 2026-06-01T23:49:50