Research Fellow: HTE Medicinal Chemistry

About This Role

Biogen is one of the world's leading biopharmaceutical companies, with a focus on developing therapies for serious conditions in neurology, immunology, and rare diseases. We are committed to research that uncovers the underlying biology of complex diseases. The High-throughput Experimentation for chemistry (HTE) platform within the Medicinal Chemistry group at Biogen is seeking a Research Fellow to conduct parallel microscale chemistry for reaction screening, optimization, and compound synthesis. The Research Fellow will design, develop, and apply novel synthetic methodologies to create automated high-throughput workflows for our reaction optimization and library synthesis capabilities. The Research Fellow role at Biogen is an 18-month position designed to provide a unique opportunity for scientists to gain exposure to drug discovery and development, high-throughput experimentation, laboratory automation, and train in an industry research setting. In this role, you will collaborate with internal drug discovery programs to deliver high-value targets through HTE.

What You'll Do

• Your focus will be to design production workflows for high-throughput experimentation in both reaction optimization and parallel medicinal chemistry with a focus on automation.
• You will have the opportunity to utilize our lab's modern chemistry equipment (UPLC-MS, automated solid and liquid handling, prep-HPLC, gloveboxes, and NMR).
• As a full member of the med chem team, you will attend project meetings and learn how to apply HTE reaction optimization and parallel synthesis to provide value for drug discovery projects.
• You will have the opportunity to present results both internally and externally via publications and/or conference presentations

Who You Are

You are a recent Ph.D. graduate with a strong organic chemistry background in synthesis, methodology, or catalysis, who is self-motivated and eager to make impactful contributions to drug discovery. You are passionate about developing novel, cutting-edge, and robust automated chemistry which can be leveraged by you and others for small molecule synthesis. You will be expected to work directly on our HTE platform, heavily integrated with laboratory automation and digital data workflows.

Required Skills

• Ph.D. in Organic Chemistry, with 0-1 years of experience.
• Excellent knowledge of synthetic organic chemistry.
• Expertise in techniques related to synthesis, purification, and characterization of organic compounds.
• Must have liquid chromatography and mass spectrometry experience specifically applied to reaction monitoring.
• Must be able to independently design, plan, execute and interpret parallel, data-driven, experiments.
• Demonstrated track record of publications, and/or scientific presentations.
• Should be able to work in a multidisciplinary team.
• Excellent oral and written communication skills.

Preferred Skills

• Familiarity with high-throughput experimentation (HTE)
• Familiarity with laboratory automation
  • Automated liquid handlers
  • Automated solid handlers
• Experience with preparative HPLC

Job Level: Professional

Additional Information

The base compensation range for this role is: -$110,000.00

Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.

Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.

In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees' and their families physical, financial, emotional, and social well-being; including, but not limited to:

• Medical, Dental, Vision, & Life insurances
• Fitness & Wellness programs including a fitness reimbursement
• Short- and Long-Term Disability insurance
• A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
• Up to 12 company paid holidays + 3 paid days off for Personal Significance
• 80 hours of sick time per calendar year
• Paid Maternity and Parental Leave benefit
• 401(k) program participation with company matched contributions
• Employee stock purchase plan
• Tuition reimbursement of up to $10,000 per calendar year
• Employee Resource Groups participation

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.

Client-provided location(s): Cambridge, MA

Job ID: Biogen-REQ22808

Employment Type: FULL_TIME

Posted: 2026-03-12T23:52:52