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CSL

Senior Clinical Statistical Programmer (Portfolio Development / Biometrics / Programming)

Berkshire, United KingdomSoftware EngineeringPosted Sep 22, 2026

Apply on company site View full job

Senior Clinical Statistical Programmer (Portfolio Development / Biometrics / Programming)

The Role

CSL is looking for a Senior Programmer to take technical ownership of one or two clinical trials from first line of code to final submission package. This is a hands-on statistical programming role with real authority attached to it: you'll be the person a study team turns to when the data needs to hold up under regulatory scrutiny, and the person who decides how a dataset gets built, not just who builds it. You'll work alongside statisticians, data managers, medical writers and regulatory colleagues as a peer, not a downstream resource - reading protocols and SAPs early enough to shape how a study's analysis gets structured, then seeing that structure through to submission-ready SDTM and ADaM datasets, TFLs, and supporting documentation.

Hybrid Based (3 days a week onsite) in Maidenhead

Why It Matters

Clinical data is only as useful as the programming behind it is trustworthy. Every regulatory decision downstream - every safety signal caught or missed, every submission accepted or queried - traces back to whether the datasets and outputs were built right the first time. This role sits at that pressure point. You're not just executing specifications; you're often the one writing them, catching the ambiguity in a protocol before it becomes a data problem three months later, and making the judgment calls that keep a study's analysis both scientifically sound and audit-ready.

What You'll Be Responsible For

You'll lead end-to-end programming for your assigned studies - in-house or outsourced - spanning the full clinical development lifecycle from study setup through analysis, reporting, and regulatory submission. That means building and validating datasets and outputs yourself where the work is done internally, and holding CRO-delivered work to the same bar where it isn't. You'll also be a technical reference point for less experienced programmers, and a contributor to how the wider programming function does its work.

• Serve as lead programmer for one or two clinical trials, interpreting protocols, SAPs, data management plans, and CRF specifications to drive study setup and analysis

• Design and validate SDTM and ADaM datasets, tables, figures, and listings, in partnership with study statisticians

• Review and take ownership of CRO-produced deliverables, ensuring submission-ready quality before they go further

• Lead specification and delivery of integrated analyses (e.g. ISS/ISE) and associated outputs when not handled by a CRO

• Mentor other programmers on internal processes and standards, and contribute to departmental tools and process improvements

• Take on ad hoc analytical work - regulatory query responses, exploratory analyses, publication support - as studies require it

Experience Required

• Experience of programming in pharmaceutical, biotech, CRO, or clinical research settings

• Strong SAS proficiency (Base/Macro/Stat/Graph); familiarity with R or other languages is a plus

• Working knowledge of current CDISC standards - CDASH, SDTM, ADaM, define.xml

• Track record of producing and validating submission-ready TFLs and datasets, including ad hoc analytical requests

• Experience supporting regulatory submissions (FDA required; PMDA, NMPA, or EMA experience a plus)

• Comfort working with external vendors and CRO-managed data

• BSc in Computer Science, Mathematics, Statistics or a related field - equivalent experience and certifications will also be considered

About CSL Seqirus

CSL Seqirus is part of CSL. As one of the largest influenza vaccine providers in the world, CSL Seqirus is a major contributor to the prevention of influenza globally and a transcontinental partner in pandemic preparedness. With state-of-the-art production facilities in the U.S., the U.K. and Australia, CSL Seqirus utilizes egg, cell and adjuvant technologies to offer a broad portfolio of differentiated influenza vaccines in more than 20 countries around the world.

To learn more about CSL, CSL Behring, CSL Seqirus and CSL Vifor visit https://www.csl.com/ and CSL Plasma at https://www.cslplasma.com/.

Our Benefits

For more information on CSL benefits visit How CSL Supports Your Well-being | CSL.

You Belong at CSL

At CSL, Inclusion and Belonging is at the core of our mission and who we are. It fuels our innovation day in and day out. By celebrating our differences and creating a culture of curiosity and empathy, we are able to better understand and connect with our patients and donors, foster strong relationships with our stakeholders, and sustain a diverse workforce that will move our company and industry into the future.

To learn more about inclusion and belonging visit https://www.csl.com/careers/inclusion-and-belonging

Equal Opportunity Employer

CSL is an Equal Opportunity Employer. If you are an individual with a disability and need a reasonable accommodation for any part of the application process, please visit https://www.csl.com/accessibility-statement.

Watch our 'On the Front Line' video to learn more about CSL Seqirus

About CSL

CSL is a leading global biotechnology company with a dynamic portfolio of lifesaving medicines and therapies

Size: 10,000+ employees
Industry: Biotechnology

View company profile

Perks and Benefits

Health and Wellness
- Health Insurance
- Dental Insurance
- Vision Insurance
- Life Insurance
- Short-Term Disability
- Long-Term Disability
- FSA
- HSA
- Mental Health Benefits
Parental Benefits
- Adoption Leave
- Birth Parent or Maternity Leave
- Non-Birth Parent or Paternity Leave
- Fertility Benefits
- Adoption Assistance Program
- Family Support Resources
Vacation and Time Off
- Paid Vacation
- Paid Holidays
- Personal/Sick Days
- Leave of Absence
- Volunteer Time Off
Financial and Retirement
- 401(k) With Company Matching
- Stock Purchase Program
- Financial Counseling
Office Life and Perks
- Commuter Benefits Program
Professional Development
- Tuition Reimbursement