Fellow - PhD

Job Description:

The SEPS lab at the Center for Integrative Brain Research, Seattle Children's Research Institute and the University of Washington invites applications for a postdoctoral position. Work in the SEPS lab focuses on shared molecular pathology among the many genetic causes of autism. We use a unique analysis platform, quantitative multiplex immunoprecipitation (QMI), to measure a network of protein-protein interactions at the glutamate synapse. This network acutely changes in response to neuronal activity or glutamate receptor agonists/antagonists, and may represent a neuronal signal transduction network. Our lab is characterizing network behavior in mouse and human iPS models of autism in order to better understand and potentially treat the disorder.

The successful candidate will perform both exacting bench work to implement the QMI assay, and advanced statistical and bioinformatics analyses on the resulting high-dimensional datasets using MatLab and R. The candidate will work closely with a technician and graduate/undergraduate students to plan and supervise several parallel lines of investigation involving primary neuronal cell culture, genetic mouse models, and human iPS cells. The candidate will be expected to independently move projects forward, write papers, and apply for F32 or equivalent grants.

The ideal candidate will have the ability to perform precise wetlab work and complex bioinformatics analyses. Prior experience with human iPS cell culture and MatLab or R programming would be beneficial. Creative, big-picture thinking and dedication to autism research are essential.

The selected candidate will join the vibrant research community at CIBR, located on the top floor of a newly renovated building in downtown Seattle. A modern, open lab space, a collegial atmosphere, on-site gym and rooftop garden, and top-of-the-line equipment, office space and meeting rooms make this an ideal training environment. Initial appointment will be for one year, with extension contingent on funding and performance.

Requirements:

Required Education/Experience: - PhD in specialty area from an accredited university training program - Experience using basic research techniques of specialty area

Preferred: - Previous experience conducting research in the pediatric arena - Experience in protocol and manuscript development and in grant writing (please see posting description for detailed information regarding other preferred experience and research project)


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