Johnson & Johnson

Senior Principal Scientist, Oligonucleotide Chemistry - Oligonucleotide Discovery, RNA & Targeted Therapeutics - South San Franc

3+ months agoSouth San Francisco, CA

Janssen BioPharma, Inc., a member of Johnson and Johnson's Family of Companies, is recruiting for a Senior Principal Scientist, Oligonucleotide Chemistry - Oligonucleotide Discovery, RNA & Targeted Therapeutics, located in South San Francisco, CA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to build a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at and follow us @JanssenGlobal. Janssen Research and Development, LLC is part of the Janssen Pharmaceutical Companies.

RNA and Targeted Therapeutics is an organization within Discovery Sciences committed to the delivery of high-quality drug candidates in the novel synthetic modalities space working closely with all six Janssen Therapeutic Areas (TA) discovery teams.

Key Responsibilities:

  • As a project leader, drive and direct oligonucleotide chemistry functions for siRNA, antisense, or other nucleic acid discovery projects, working in concert with partners in molecular and cellular biology, pharmacology, computational chemistry, ADME, structural biology, chemical development, and other key functions
  • Serve as a scientific expert in nucleic acid drug discovery with both internal and external partners and provide recommendations regarding new targets and emerging external opportunities
  • Provide scientific direction and leadership for oligonucleotide and synthetic chemistry activities of internal & external FTEs
  • Supervise and direct synthetic chemistry activities at contract research organizations (CROs)
  • Maintain a significant level of knowledge and management of laboratory research, and executes synthesis, purification, and characterization of oligonucleotides in the lab
  • Analyze screening data, perform literature reviews, design, propose, and execute nucleic acid chemistry plans, coordinate chemistry and biology data to support oligonucleotide compound progression and patent strategies
  • Ensure efficient interaction/communication and provide updates on project status to Discovery Sciences leadership

  • PhD in synthetic organic or medicinal chemistry or nucleic acid chemistry or other related chemistry field is required
  • Postdoctoral experience with an emphasis on oligonucleotide or nucleoside chemistry is preferred
  • At least 6 years experience in the biopharmaceutical or biotechnology industry is required
  • A proven track record of leading innovative oligonucleotide discovery projects, especially in siRNA therapeutics, is preferred
  • Experience as a project leader in the biopharmaceutical industry is strongly preferred
  • Experience in one or more therapeutic areas/oligonucleotide modalities is preferred
  • Expert knowledge of modern methods of synthetic chemistry with an emphasis on oligonucleotide synthesis and characterization is preferred
  • Expertise in nucleic acid modalities, modification chemistries, sequence selection, and mechanism of action is preferred
  • Strong track record of scientific contributions including peer reviewed first-author publications, patent applications, and/or presentations at major national meetings is preferred
  • Maintaining a very productive lab presence is required.
  • This position is located in South San Francisco, CA, and may require up to 10% travel

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.


Primary Location
United States-California-South San Francisco-260 E. Grand Avenue
Janssen BioPharma, Inc. (6224)
Job Function
Requisition ID