POSTDOCTORAL RESEARCH FELLOW- GENERATION AND CHARACTERIZATION OF CAR-T CELLS
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Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. JanssenBioTherapeuticsis searching for an energetic, highly-motivated Postdoctoral Fellow to work on the generation and characterization of CAR-T therapeutics. CAR-T cell immunotherapies show impressive clinical responses, with two CAR-T cell products approved by the FDA for the treatment of B cell malignancies. However, current CAR-T cells are engineered from patient-specific T cells, which manifest a number of key shortcomings: a) inefficient anti-tumor response in solid tumors; b) limited penetration and susceptibility of adoptively transferred CAR-T cells to immunosuppressive TME; c) poor persistence of CAR-T cells in vivo, and d) serious adverse events in the patients. This creates an unmet medical need for novel cellular therapies that can overcome these challenges. The research fellow will be developing an off-the-shelf, T cell-based allogenic cellular therapy strategy with the potential to alleviate some of these concerns and provide a better efficacy profile, including against solid tumors. The successful candidate will be investigating how the phenotype of the CAR-T cells dictates their activity, persistence, and toxicity in the context of anti-tumor immunity and will be generating CAR-T cells using various methods and assess their phenotypes. They willpartner throughout the Janssen R&D organizationand participate in cross-functional team discussions,gaininginsight into many aspects ofbiotherapeutic discovery and development. ThePostdoctoral Fellowis expected to author papers on theirresearchand present novel findings atscientificconferences.
Suitable candidates will havea PhD inimmunology,immuno-oncology, or a related field. Research experience in one or more of the following areas is preferred:
- Working background in CAR-T biology
- Hands onexperience in cell biology, genetic engineering, and assay development
- Research background in macrophage and/or NK cell biology
- A working knowledge of gene-editing technologies including CRISPR, TALENs, transposons, and related applications
Candidatesmustdisplay an ability to independently design and execute research.In addition to a broad knowledge of immunology and oncology, we are seeking an individual with deep intellectual curiosity, and excellent communication and interpersonal skills.
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
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Janssen Research & Development, LLC (6084)
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