Howard Hughes Medical Institute

Postdoctoral Associate - Parkinson's Disease

3+ months agoLa Jolla, CA

Primary Work Address: Leichtag Biomedical Research Building, La Jolla, CA, 92093-0646

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We are currently looking for a Postdoctoral Associate to join the laboratory of Dr. Samara Reck-Peterson at the University of California, San Diego (UCSD) in San Diego, California. This role will join an HHMI and Aligning Science Across Parkinson's ( -funded project at the Reck-Peterson lab ( to study the role of LRRK2 in Parkinson's disease. The project will use ES and iPS cell culture, gene-editing, advanced live-cell imaging, and proteomics to determine the functions of LRRK1 and LRRK2 in normal cells and the role of LRRK2 in Parkinson's Disease. The lab is also expert in single-molecule biophysics and in vitro reconstitution and we collaborate with the Leschziner lab at UC San Diego to solve protein structures by cryo-electron microscopy. See our recent paper in Nature ( describing the structure of LRRK2 and how LRRK2 acts as a roadblock for the microtubule-based motors kinesin and dynein.


A Ph.D. in the biological, biophysical, or biochemical sciences is required.


Experience in CRISPR-based gene editing and live-cell imaging is required.

Experience in biochemistry and proteomics is preferred.

Application Instructions

  • Please include both your CV and a cover letter as part of your application.

  • Please have three referees send letters of recommendation directly to rplabjobs (at)

Physical Requirements

Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet).

Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.

Please Note:

This job description sets forth the job's principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word "may," the Essential Duties and Responsibilities described above are "essential functions" of the job, as defined by the Americans with Disabilities Act.

HHMI is an Equal Opportunity Employer