Howard Hughes Medical Institute

Postdoctoral Associate - Parkinson's Disease

2 months agoLa Jolla, CA

Primary Work Address: Leichtag Biomedical Research Building, La Jolla, CA, 92093-0646

Current HHMI Employees, click here to apply via your Workday account.

We are currently looking for a Postdoctoral Associate to join the laboratory of Dr. Samara Reck-Peterson at the University of California, San Diego (UCSD) in San Diego, California. This role will join an HHMI and Aligning Science Across Parkinson's (https://parkinsonsroadmap.org/) -funded project at the Reck-Peterson lab (http://reck-peterson.ucsd.edu) to study the role of LRRK2 in Parkinson's disease. The project will use ES and iPS cell culture, gene-editing, advanced live-cell imaging, and proteomics to determine the functions of LRRK1 and LRRK2 in normal cells and the role of LRRK2 in Parkinson's Disease. The lab is also expert in single-molecule biophysics and in vitro reconstitution and we collaborate with the Leschziner lab at UC San Diego to solve protein structures by cryo-electron microscopy. See our recent paper in Nature (https://www.nature.com/articles/s41586-020-2673-2) describing the structure of LRRK2 and how LRRK2 acts as a roadblock for the microtubule-based motors kinesin and dynein.

Education

A Ph.D. in the biological, biophysical, or biochemical sciences is required.

Experience

Experience in CRISPR-based gene editing and live-cell imaging is required.

Experience in biochemistry and proteomics is preferred.

Application Instructions

  • Please include both your CV and a cover letter as part of your application.
  • Please have three referees send letters of recommendation directly to rplabjobs (at) gmail.com.

Physical Requirements

Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet).

Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.

Please Note:

This job description sets forth the job's principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word "may," the Essential Duties and Responsibilities described above are "essential functions" of the job, as defined by the Americans with Disabilities Act.

Compensation and Benefits

Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our Benefits at HHMI site to learn more.

HHMI is an Equal Opportunity Employer

Client-provided location(s): La Jolla, San Diego, CA, USA
Job ID: HHMI-R-175

Perks and Benefits

  • Health and Wellness
    • FSA
    • HSA
    • Health Reimbursement Account
    • Fitness Subsidies
    • On-Site Gym
    • Health Insurance
    • Dental Insurance
    • Vision Insurance
    • Life Insurance
    • Short-Term Disability
    • Long-Term Disability
  • Parental Benefits and Childcare
    • Paid Family Leave
  • Office Life and Perks
    • Commuter Benefits Program
    • Happy Hours
    • Snacks
  • Vacation and Time Off
    • Personal/Sick Days
    • Paid Holidays
    • Paid Vacation
  • Financial and Retirement
    • 401(K) With Company Matching
    • 401(K)
  • Professional Development
    • Learning and Development Stipend
    • Access to Online Courses
    • Tuition Reimbursement
  • Diversity and Inclusion
    • Diversity, Equity, and Inclusion Program

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