Postdoctoral Associate

About HHMI

Howard Hughes Medical Institute (HHMI) is a science philanthropy whose mission is to advance biomedical research and science education for the benefit of humanity. We empower exceptional scientists and students to pursue fundamental questions about living systems, and work to share scientific discoveries with researchers, students, and science-curious individuals around the world. Founded in 1953 by aviator and industrialist Howard R. Hughes, HHMI is headquartered in Chevy Chase, Maryland, and employs more than 2,500 people across the U.S. Visit to learn more about working at HHMI.

Postdoctoral Scholar position at UC-Berkeley:

Host Pathogen and Psychiatric Cell Map Initiatives - HPMI and PCMI

The Departments of Molecular and Cellular Biology (MCB) and Chemistry at The University of California, Berkeley invite applications for a Postdoctoral Scholar - Employee position starting in late 2018 or early 2019. This position will split their time between two new "Map Initiatives" in collaboration with Nevan Krogan, Jeff Cox, Alex Marson, and others. Both projects are designed to interrogate genetic and proteomic network effects, and relate those to disease phenotypes.

Genomic studies, focusing on high effect size rare variants, have revealed dozens of genes linked to distinct psychiatric disorders, including autism spectrum disorders (ASD). However, it remains completely unclear how mutations in these genes result in these disorders. In order to truly understand the pathobiology, one needs to study these genes in the context of functional pathways and networks, and how these relate to higher-order phenotypes. The Psychiatric Cell Map Initiative (PCMI) is seeking to understand ASD, with an overarching goal of connecting genetics to neurobiology, and ultimately, the clinic. The major goal of PCMI is to uncover functional relationships between the large number of genes definitively associated with ASD and emergent higher-order phenotypes, enabling novel therapeutics.

Prevention and treatment of bacterial infection sis a critical challenge facing the international biomedical community. A central problem that we address here is our limited understanding of the host/pathogen molecular interactions that occur during infection. We propose an unbiased systems-level approach to uncover how host innate immune cells recognize and respond to bacterial pathogens. The Host Pathogen Map Initiative (HPMI) is focused on M. tuberculosis (which is responsible for 1.3 million deaths annually) and S. aureus (which causes a number of life-threatening illnesses).

This postdoctoral position will employ diverse genetic techniques including multiplexed CRISPR screening, high-throughput single cell RNA-sequencing, and in vivo neuronal editing to probe genetic interactions required for disease initiation and maintenance. This researcher will design, implement, and improve new CRISPR-based genetic technologies to perform screens and analysis for use by both Centers. Further, they will refine the CRISPR technologies used to develop gene knockout methodologies in human macrophages to be used for subsequent infection studies, create epitope-tagged alleles of endogenous genes for mass spec-based interaction mapping, and to further our understanding of the complex genetic interaction networks related to ASD. This person will work in the laboratory of Jennifer Doudna (MCB) and will closely collaborate the other groups involved on this project.

Position Qualifications: A Ph.D. with a strong background in molecular biology, biochemistry, genomics, or related disciplines is required. Experience with working in teams, as well as an ability to work independently, is essential. Applicants should submit a CV and a summary of research experience.. Three (3) confidential letters of reference should be sent under separate email cover. Minorities and women encouraged to apply. University of California is an EOE/AAE. UC Berkeley postdoctoral salary rates are according to published scale, based on experience level.

HHMI is an Equal Opportunity Employer

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