Upstream Cell Culture Investigator
Site Name: UK - Hertfordshire - Stevenage
Posted Date: Jan 10 2020
BioPharm Process Research (BPR) is an early process development function responsible for accelerating biopharmaceutical assets into clinical manufacture by linking drug discovery and product development. As part of this wider group the Upstream Process Research group is responsible for cell line selection, the development of bioreactor production processes and their subsequent transfer to GSK's large-scale clinical manufacturing facilities in the US and to other external partners to support the progression of GSK's innovative early stage Biopharm portfolio which includes monoclonal antibodies, bispecific antibodies and recombinant proteins.
Our recent investment in automated upstream and cell line development processes, combined with cutting edge analytical techniques and advanced data analysis is enabling us to better understand our platform processes and increase our metabolic and biochemical knowledge of our cell lines. We are now looking to leverage these enhanced datasets to drive better cell line selection by linking cell line biology to subsequent process performance.
You will be a highly motivated and experienced 'hands on' bioprocess engineer who will link cell line selection to performance at manufacturing scale by working closely with our cell line development, disruptive technology and manufacturing groups to develop effective scale down models to enhance cell line selection to support our End to End Biopharm capability and Single Cycle Development
- Link cell line performance at ambr15 scale to manufacturing scale bioreactor performance by developing models to enhance the scalability of our bioreactor systems
- Use cross-scale metabolic, biochemical, spectral and engineering data to enhance process transfer by connecting ambr15 and manufacturing scale performance
- Leverage manufacturing scale data to deliver a better understanding of our cell lines to enhance 'right first time' cell line selection
- Deliver our OneStream vision to facilitate Tech Transfer by proposing and leading focused experimental work packages to enhance cell line selection and cell line performance in our platform processes.
- Contribute to our End to End Biopharma vision through collaboration with our wider drug discovery and process groups to leverage cell biology information for improved process performance.
- Contribute to wider automation, data analysis and bioinformatic work packages within BPR to support our End to End Biopharma capability.
- PhD in Biochemical engineering, Bioprocess Science or Biochemistry
- Extensive practical experience of mammalian cell culture at bench and bioreactor scale
- Track record of design, execution and analysis of work packages to improve CHO cell performance through data driven cross-scale modelling
- Ability to proactively contribute to team performance and process improvement in a climate of scientific rigor across multiple CHO process science groups
- Effective communication skills
- Knowledge of, and ability to apply, experimental design and data analysis principles to derive quality results in a timely fashion
- Proven experience of evaluation and implementation of appropriate new ideas and technologies
- Ability to apply innovative solutions to process development problems
- Understanding of cell line selection and process development in an industrial setting and the ability to proactively contribute to data driven continuous process improvement
As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers. As a candidate for a role, we want you to feel the same way.
We're open to all talent - whatever your gender, disability, marital status, religion or belief, age, race, sexual orientation, ethnic or national origin.
We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
Please don't hesitate to contact us if you'd like to discuss any adjustments to our process which might help you demonstrate your strengths and capabilities. You can either call us on 0808 234 4391, or send an email firstname.lastname@example.org
As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.
Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.
Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.
Back to top