Sr. Director - Oncology Synthetic Lethality Discovery

    • Collegeville, PA

Site Name: USA - Pennsylvania - Upper Providence
Posted Date: May 8 2020
Are you energized by a scientific leadership role that allows you to enhance scientific capabilities and foster an environment of new ideas and innovation? If so, this Sr Director - Synthetic Lethality (Oncology), role could be an ideal opportunity to explore.

This is a scientific leadership role within GSK's growing and dynamic oncology organization. The synthetic lethality research unit is one of four pre-clinical research units, designed to take advantage of the growing revolution in clinical and experimental cancer genomics data.

The successful candidate will serve as part of the unit leadership team and personally direct a research group responsible for the development of a synthetic lethality based oncology portfolio from target initiation through early clinical development. Department activities include target identification, target validation, support of discovery efforts through cellular and mechanistic biology, development of clinical PD biomarkers, and combination discovery efforts.
The successful candidate will also foster cross-functional partnerships with GSK's discovery, clinical, biomarker, functional genomics, and human genetics groups, as well as provide input into GSK's external investments in the field.

DUTIES & RESPONSIBILITIES:

The successful applicant's responsibilities will include:

  • Using data from existing genome wide SL screens and cancer genomics data sources, develop pipelines to identify, prioritize, and validate SL targets.
  • In partnership with GSK's functional genomics partners, develop differentiated CRISPR screen ideas and validate arising targets.
  • Work with the research unit head to analyze potential external investments in programs and technologies and prepare presentations for GSK governance boards to secure funding.
  • Serve as member of the research unit (RU) leadership team, along with the RU head and 2 other senior directors (all based in Boston).
  • Direct a group of 10-15 scientists, developing the drug discovery expertise of cancer biologists in the group.
  • Serve as program lead for cross-functional drug discovery programs, managing activities across discovery matrix experts. Work with clinical and companion diagnostics/ biomarker lead to ensure alignment of preclinical and clinical biomarker strategies
  • Champion GSK cultural and scientific and pillars, including single point of accountability, smart risk taking, and following the science.
  • Lead the writing and editing of documentation for regulatory filings including the biology sections of clinical protocols and investigator brochures.

QUALIFICATIONS:

Minimum Education :
Ph.D. in cancer biology or related fields

Preferred Education:
Same as minimum

Job Experience:
  • A minimum of 10 years of pharmaceutical industry experience in oncology discovery and/or clinical development across a diverse set of drug targets and therapeutic modalities
  • Significant experience managing and leading scientific teams with a track record of developing talent
  • Proven track record of delivering oncology assets into the clinic in partnership with translational medicine groups
  • Literacy/knowledge on how to leverage cancer genomics data and analysis methods for discovery efforts
  • Understanding of clinical trial design and execution (efficacy endpoints, biomarker testing)

Other Job-Related Skills (Desirable)
  • Experience in managing research collaborations, contract laboratories and budgets
  • Demonstrated scientific capability as evidenced by publications, research reports, and external presentations.
  • Effective verbal and written communication skills relating to colleagues and associates both inside and outside the corporation
  • Ability to productively collaborate with multiple groups in a matrix environment
  • Detailed oriented with strong organizational skills in order to manage and meetdeliverables
  • Flexibility to work on multiple projects as the portfolio evolves over time.

Why GSK?

Our values and expectationsare at the heart of everything we do and form an important part of our culture.
These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork.As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
  • Agile and distributed decision-making - using evidence and applying judgement to balance pace, rigor and risk.
  • Managing individual and team performance.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Implementing change initiatives and leading change.
  • Sustaining energy and well-being, building resilience in teams.
  • Continuously looking for opportunities to learn, build skills and share learning both internally and externally.
  • Developing people and building a talent pipeline.
  • Translating strategy into action - a compelling narrative, motivating others, setting objectives and delegation.
  • Building strong relationships and collaboration, managing trusted stakeholder relationships internally and externally.
  • Budgeting and forecasting, commercial and financial acumen.

*This is a job description to aide in the job posting, but does not include all job evaluation details.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).
GSK is an EqualOpportunity/AffirmativeAction Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

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