Senior Scientist, Genomics

    • Collegeville, PA

Site Name: USA - Pennsylvania - Upper Providence
Posted Date: Feb 24 2020
We have an exciting opportunity for a highly motivated, agile and experienced scientist with lab level expertise in genomic technologies to join the Cellular Biomarkers Genomics group within the Bioanalysis, Immunogenicity and Biomarkers (BIB) department based in Collegeville, PA.

This individual will serve as a technical expert in applied genomic technologies and will generate data to support the understanding of disease heterogeneity, drug's mechanism of action, and patient response to treatment at the molecular level through application of advanced genomic technologies, including Next Generation Sequencing (NGS), single cell analysis, Nanostring, qPCR, etc.

This role will conduct and oversee all aspects of the method development, trouble-shooting, validation and sample analysis for clinical studies requiring genomic technologies endpoints including reagent selection/optimization, sample preparation, sample acquisition and data processing. They will ensure all work is conducted in compliance with GCLP regulations and follows the appropriate SOPs.

Key Responsibilities:

  • Be responsible for developing genomic assays using applied genomic technologies to support clinical studies; delivery of robust, high quality data packages
  • Collaborate with Biomarker Leads and provide biomarker assay support to deliver on biomarker strategy as defined by project needs.
  • Work with data management, programming and bioinformatics scientists to expedite the transfer of biomarker data to clinical teams
  • Investigate novel genomic platforms and imbed within the organization
  • Act as subject matter expert for the transfer of assays to CROs
  • Willingness to develop and train others as required
  • Handling of human biological samples and performing experimental work in accordance with safety requirements, data integrity and GCLP guidelines.

Why you?
Basic Qualifications:
We are looking for professionals with these required skills to achieve our goals:
  • B.S./M.S. degree with hands on research experience in genomics, NGS, molecular or cellular biology or related disciplines
  • Knowledge of current genomic analytical platforms (e.g., RNA-Seq, microbiome, qPCR, Nanostring)
  • Ability to provide guidance on the use of NGS and digital quantification of nucleic acids to support clinical sample testing

Preferred Qualifications:
If you have the following characteristics, it would be a plus:
  • Experience in designing, troubleshooting and implementing single cell RNA-seq applications or similar high content techniques (e.g., BD Rhapsody, 10x Genomics)
  • Maintains a disciplined approach, ensuring a relentless focus on quality, compliance, scientific rigor and operational excellence
  • Collaboration and interpersonal skills to work well with colleagues from all phases of clinical drug development and influence biomarker testing strategies
  • Proactively demonstrate the ability to work in tight deadlines; both independently and in a team.
  • Experience in the development and validation of novel genomic assays to support clinical measurements and their translation to a companion diagnostic (CDx) when applicable.
  • Experience of working with external vendors for the transfer of assay to support clinical trial sample analysis and development of CDx

Why GSK?
Our values and expectations are at the heart of everything we do and form an important part of our culture.
These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

Operating at pace and agile decision-making - using evidence and applying judgment to balance pace, rigor and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness

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