Senior Scientist

    • Collegeville, PA

Site Name: USA - Pennsylvania - Upper Providence
Posted Date: May 11 2020
An opportunity has risen for a highly motivated and creative scientist to join a protein sciences group in the department of Protein, Cellular, and Structural Sciences at GSK's facility in Upper Providence, Pennsylvania. The primary responsibility of the department is to design, generate and validate biological reagents for discovery activities across all of GSK's therapeutic modalities. The department also provides the structural and mechanistic understanding of drug target, molecular recognition and mode of action to deliver the best molecule.

This is a laboratory role in which the individual's primary responsibility is to design and deliver custom protein reagents to fill the needs of uHTS assays, protein structural determination, and biophysical studies in preclinical drug discovery. The individual will be responsible for developing automated protein expression and purification methods as well as assisting with the expression of complex proteins. The ideal candidate for this role will have skills in protein expression/analysis and experience in both bacterial and mammalian expression systems. Experience carrying out automated methods for protein expression and purification would be desirable. The appointee will be capable of good experimental record-keeping and will have excellent written and oral communication skills. He/she will be expected to attend project meetings and contribute to project teams in a collaborative manner. An ability to work towards agreed timelines and effectively organize their work will be considered a key asset of the successful applicant.

Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals:

  • A BS with 3 + years relevant industry experience or MS with 1 + years in a life sciences discipline (e.g. molecular biology, biochemistry) is required.
  • Demonstrated laboratory experience in molecular biology, construct generation and recombinant protein expression.
  • Experience with cell culture and transfection techniques
  • Familiarity with standard protein characterization/analytical methods such as standard and SDS-PAGE/ Western blotting.
  • Experience with data-set handling software such as Excel
  • Good record keeping skills
  • Track record of flexibility and team work.
  • Good written and verbal communication skills.

Preferred Qualifications: If you have the following characteristics, it would be a plus:
  • Experience with automation platform programming and scripting, e.g. Tecan Freedom EVOware.
  • Ability to support reagent production timeline goals, generating fit-for-purpose reagents for assays, x-ray crystallography, cryo-EM, protein NMR, biophysics, and enzymology
  • Experiences in high throughput small scale expression as well as scale-up expression
  • Familiarity with the used of automated liquid handlers such as the KingFisher or Tecan robots.
  • Practical knowledge in high throughput cloning and sequencing analysis
  • Ability to plan, execute and evaluate multiple scientific strategies in parallel where appropriate

Please use the cover letter to highlight how you meet the competencies for the role. Your cover letter along with your CV will be used to assess your application. Thanks for your interest in this opportunity.

Why GSK?
Our values and expectationsare at the heart of everything we do and form an important part of our culture.
These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
  • Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being.
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness.


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