Scientific Leader DMPK Modeling
- Collegeville, PA
Site Name: UK - Hertfordshire - Stevenage, USA - Pennsylvania - Upper Providence
Posted Date: Jun 1 2020
GSK is seeking a highly motivated and experienced mechanistic modeling scientist to join our recently formed Drug Metabolism and Pharmacokinetics modeling team. As a scientific leader with supervisory responsibility, the successful applicant will develop and drive the preclinical PK/PD strategy for projects with the aim to deliver a robust prediction of the human efficacious dose.
Key Responsibilities include:
•Interface with the therapeutic areas, acting as point of contact between DMPK, and other discovery (chemistry, biology, safety), and development colleagues to design and analyse the appropriate preclinical studies.
• Responsible for project deliverables, including prediction of human PK, preclinical and translational PK/PD work in projects from target validation to candidate selection and human dose in conjunction with DMPK modeling director, clinical pharmacologists, translational scientists and the DMPK Project Representative.
• Establish and implement PK/PD strategies to facilitate continuous improvement of human dose prediction.
•Interface with biology and clinical teams to implement biomarker strategy
•Evaluate and interpret PK/PD data to prepare for internal governance bodies.
• Work with DMPK modeling scientists, DMPK Project Representatives, functional lines and other enterprise business partners to assure timely project issue resolution
• Drive the rapid development of applied modeling innovation in partnership with external and internal groups
• Present work at cross-functional teams, departmental meetings
• Provide expert DMPK modeling consultancy, training and support to scientists within the DMPK organization and across the larger R&D
• Active engagement with external modeling community and maintain awareness of new /emerging techniques relevant to the field.
•Manage student and post doc programmes
•Act as mentor to junior staff within the DMPK modeling team
Basic Qualifications The ideal candidate will be/have:
- A successful track record of applying translational PK/PD modeling within the drug discovery and development environment.
- Experience in providing PK/PD input into early preclinical in vivo studies
- Understanding of the principles of ADME and pharmacokinetics, (non-compartmental, compartmental, PBPK) and the use of pre-clinical data for human efficacious dose prediction.
- Experience in PK data interpretation of a range of clinical studies
- Experience in DMPK project co-ordination.
- Experience of interacting with regulatory agencies in the area of modeling and simulation.
- The ability to work independently, excellent interpersonal, organizational, oral/written communication and teamwork skills
- Ability to multi task and prioritize to deliver results within tight timelines when required.
- Active contributions to external consortia; presenting at conferences and contribution to scientific publications.
- Advanced degree (PhD) in relevant scientific discipline (e.g. Pharmacology, pharmaceutical sciences), with several years' experience in DMPK and PK/PD within a drug discovery environment.
If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).
GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.
Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.
Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.
Back to top