Protein and Cell Science- CryoEM Protein Biochemist

    • Stevenage, United Kingdom

Site Name: UK - Hertfordshire - Stevenage
Posted Date: Sep 15 2020

We are currently expanding our CryoEM capability and an exciting opportunity has arisen for a highly motivated protein biochemist with an interest in sample preparation for EM analysis, to join the department of Protein and Cell Sciences at GSK's Medicines Research Centre in Stevenage (PCS UK). The department is engaged in the design, generation and validation of biological reagents to support drug discovery across all of GSK's therapeutic modalities.
You will be a self-motivated protein biochemist with a strong interest in protein expression and purification. You will be responsible for sample generation for CryoEM analysis including the generation and isolation of novel proteins and protein complexes and will work closely with the Structure and Biophysics group at GSK. The ideal candidate for this role will have skills in protein expression, purification, protein isolation as well as experience with sample preparation for CryoEM.
Key Responsibilities:

  • Expression and purification of proteins from a range of expression systems.
  • Protein isolation from endogenous systems
  • Purification of protein complexes and membrane proteins
  • Optimisation for EM sample preparation
  • Protein analytical and biophysical characterisation of prepared samples
  • Molecular biology design and construct generation
  • Teamwork within project teams and department
  • Record keeping of experiments
  • Proactive in bringing in new technologies and ways of working; sharing these with the department

Closing date 13th October 2020
Please take a copy of the Job Description, as this will not be available post closure of the advert.

When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

Why you?
Basic Qualifications:
We are looking for professionals with these required skills to achieve our goals:

  • We are looking for professionals with these required skills to achieve our goals:
  • A background in a biological or biochemical sciences discipline, PhD level or equivalent
  • Deep expertise in Pro
  • Extensive experience of expression and purification of proteins from a range of expression systems.
  • Knowledge of protein isolation from endogenous systems
  • Experience with optimisation methods for CryoEM sample preparation
  • Thorough knowledge of protein analytical and biophysical characterisation techniques
  • Track record of flexibility and team work.
  • Good written and verbal communication skills.
  • Good record keeping skills

Preferred Qualifications: If you have the following characteristics, it would be a plus:
  • Experience of purification of protein complexes and membrane proteins
  • Experience with mammalian and insect cell culture, transfection and expression techniques
  • Experience with molecular biology design and construct generation.

Why GSK?

At GSK, we're a company with a special purpose, to help people do more feel better and live longer. Realising our purpose starts with us. When we feel at our best, we perform at our best.
When you set out on your adventure at GSK, we make a deal. You commit to living GSK's values and expectations and performing against our Innovation, Performance and Trust priorities. And in return, GSK commits to providing the right environment for you to thrive. Put simply, it's about you being motivated to do your best work, in a place where you can be you, feel good and keep growing.
Together we build an environment where we can all thrive and focus on what matters most to each of us. It is only through the energy, dedication, drive and passion of all of us that we can be the very best for GSK, and importantly, for our patients and consumers.

As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers. As a candidate for a role, we want you to feel the same way.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class
(*US only).

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Please don't hesitate to contact us if you'd like to discuss any adjustments to our process which might help you demonstrate your strengths and capabilities. You can either call us on 0808 234 4391, or send an email

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