Protein and Cell Science- CryoEM Protein Biochemist
- Stevenage, United Kingdom
Site Name: UK - Hertfordshire - Stevenage
Posted Date: Sep 15 2020
We are currently expanding our CryoEM capability and an exciting opportunity has arisen for a highly motivated protein biochemist with an interest in sample preparation for EM analysis, to join the department of Protein and Cell Sciences at GSK's Medicines Research Centre in Stevenage (PCS UK). The department is engaged in the design, generation and validation of biological reagents to support drug discovery across all of GSK's therapeutic modalities.
You will be a self-motivated protein biochemist with a strong interest in protein expression and purification. You will be responsible for sample generation for CryoEM analysis including the generation and isolation of novel proteins and protein complexes and will work closely with the Structure and Biophysics group at GSK. The ideal candidate for this role will have skills in protein expression, purification, protein isolation as well as experience with sample preparation for CryoEM.
- Expression and purification of proteins from a range of expression systems.
- Protein isolation from endogenous systems
- Purification of protein complexes and membrane proteins
- Optimisation for EM sample preparation
- Protein analytical and biophysical characterisation of prepared samples
- Molecular biology design and construct generation
- Teamwork within project teams and department
- Record keeping of experiments
- Proactive in bringing in new technologies and ways of working; sharing these with the department
Closing date 13th October 2020
Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
We are looking for professionals with these required skills to achieve our goals:
- We are looking for professionals with these required skills to achieve our goals:
- A background in a biological or biochemical sciences discipline, PhD level or equivalent
- Deep expertise in Pro
- Extensive experience of expression and purification of proteins from a range of expression systems.
- Knowledge of protein isolation from endogenous systems
- Experience with optimisation methods for CryoEM sample preparation
- Thorough knowledge of protein analytical and biophysical characterisation techniques
- Track record of flexibility and team work.
- Good written and verbal communication skills.
- Good record keeping skills
Preferred Qualifications: If you have the following characteristics, it would be a plus:
- Experience of purification of protein complexes and membrane proteins
- Experience with mammalian and insect cell culture, transfection and expression techniques
- Experience with molecular biology design and construct generation.
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