Investigator, LC/MS Protein Characterization
- Collegeville, PA
Site Name: USA - Pennsylvania - Upper Providence
Posted Date: Dec 9 2020
GlaxoSmithKline has an immediate opening for an Investigator position - HPLC mass spectrometry, proteomics, and protein characterization in Collegeville, PA. This role will be primarily responsible for developing mass spec based strategies & methods (e.g. LC-MS and LC-MS/MS) and performing analysis for the characterization and comparability evaluation of therapeutic proteins. They will also develop and apply methods, including nano-LC-MS/MS, for the identification and analysis of residual host cell proteins [HCPs]. The candidate is also expected to develop other analytical and/or biochemical methods to deepen the understanding of protein structure and function relationships, and participate in supporting FTIH through to commercial biopharmaceutical process development and manufacturing.
The mass spec group is well equipped with modern instrumentation including Synapt G2S with both H/DX and IM, Xevo G2-XS, Orbitrap Fusion Tribrid, Orbitrap XL, Exploris 480, Eclipse Tribrid, Q Exactive Plus, 2D-NanoUPLC, Nano-UPLC, UPLC and many other supporting instrumentation and associated data analysis software packages.
Why you? Basic Qualifications:
We are looking for professionals with these required skills to achieve our goals:
- MS with more than 5+ years of experience in biotech or pharmaceutical industry or Ph.D.
- Experience in protein characterization mass spectrometry, with hands-on experience on various high-resolution accurate mass LC/MS instruments operation, nano-LC fluidics and LC-MS/MS methods, data processing software and workflows.
- Prior experience in developing cutting-edge LC-MS/MS workflow for proteomics analysis, particularly for the host cell proteins (HCPs) analysis
If you have the following characteristics, it would be a plus:
- Experience in analysis of protein therapeutics using both platform assays like intact/reduced, peptide mapping as well as technologies like HDX-MS and structure modeling to understand structure and function relationships
- Excellent scientific and working knowledge in structure and functions of protein glycosylation, prior experience in glycan and/or glycomics analysis
- In-depth knowledge and hands-on experience in various separation techniques such as CE, SEC, IEX and HPLC/UPLC
- Experience in supporting FTIH through to commercial stage of biopharmaceutical development
- The candidate is expected to be highly motivated with excellent communication skills, both written and verbal. Candidate should be an instinctive team player with excellent people skills.
Our values and expectations are at the heart of everything we do and form an important part of our culture.
These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
- Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
- Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
- Continuously looking for opportunities to learn, build skills and share learning.
- Sustaining energy and well-being.
- Building strong relationships and collaboration, honest and open conversations.
- Budgeting and cost-consciousness.
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