Investigator (In Vivo Pharmacology) Oncology

    • Cambridge, MA

Site Name: USA - Massachusetts - Cambridge
Posted Date: Sep 14 2020
Are you energized by the challenge of shaping and accelerating the scientific expertise of a biology program? If so, our Oncology Synthetic Lethality Research Unit's Investigator (In Vivo Pharmacology) Oncology role could be an exciting opportunity to consider.

As an Investigator (In Vivo Pharmacology) Oncology, you will be responsible for working together with a highly motivated team while providing advanced biology expertise to the biology group.

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following :

  • Independently execute on a variety of complex invitro models (organoids, spheroids) and in vivo techniques across different projects to support and deliver high quality data.
  • Plan, execute and analyse data to effectively achieve project goals and timelines.
  • Discover and develop novel oncology drugs with a clear genetic relationship to cancer.


Why you?
Basic Qualifications: We are looking for professionals with these required skills to achieve our goals:
  • PhD in Cell Biology, Molecular Biology, Biochemistry, Pharmacology, or related life sciences field with strong scientific background in in vivo oncology or non-PhD with 10-15 years pharmaceutical experience.
  • Experience in ex-vivo spheroid/organoid culture assays.


Preferred Qualifications: If you have the following characteristics, it would be a plus:
  • Demonstrated ability to design, conduct, and analyze data from in vivo pharmacology studies.
  • Strong organizational skills and the ability to manage multiple priorities in a matrix environment.
  • Experience in in vivo models including- cell culture, compound preparation and formulation, administration (e.g. i.v., s.c., p.o.), CDX, PDX, and syngeneic model implantation and measurement.
  • Demonstrated expertise including PK/PD, efficacy and biomarker studies to inform patient selection strategies, dose and schedule optimization, and identify rationale drug combinations.
  • Experience in developing and executing CRISPR for target validation and MOA studies will be a definitive plus.
  • Ability to lead from the bench in problem solving and the development of innovative solutions.
  • Excellent communication and presentation skills.
  • A proven track record of high productivity and scientific publications in peer reviewed journals.


Why GSK? Our values and expectationsare at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
  • Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being.
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness.
*LI-GSK

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