Investigator, Cellular Mass Spectrometry
- Stevenage, United Kingdom
Site Name: UK - Hertfordshire - Stevenage
Posted Date: Apr 8 2020
Investigator, Cellular Mass Spectrometry UK
(Senior Scientist level will also be considered dependent on relevant experience).
We have an exciting new position available within our Bioimaging group at GSK. This role is based from our R&D site at Stevenage, UK.
You will work as part of the Cell Imaging & Dynamics group within the Ultrastructural and Cellular Bioimaging team to provide critical mass spectrometry data to progress the development of new medicines across a range of projects supporting the research units and wider GSK. The team continues to pioneer leading edge technology through extensive external collaborations and to develop these approaches to deliver enhanced knowledge of compound distribution and its concomitant outcomes on biological processes. Your role will contribute to this advancement, with a focus on the application of advanced mass spectrometry, ensuring that critical information is available to enable timely decision making. Hence, it is key to this role that you have a deep knowledge of high sensitivity mass spectrometry and its application to characterising biological pathways, both in relation to disease and normal biological function. An understanding of mass spectrometry imaging would be an advantage but given the cutting-edge nature of the systems used, the successful applicant will receive full training.
Bioimaging at GSK
At our world class scientific hub Hertfordshire, UK, our Bioimaging department brings together key areas of in-vivo and ex vivo imaging combined with histology to understand both disease state and intervention, combining data on drug distribution with the effect that distribution has on intact biological systems. The focus of the newly formed Ultrastructural and Cellular Bioimaging group is to support all aspects of Research, and the wider GSK, using Bioimaging and multiplexed histology at cellular & ultrastructural resolutions. As well as using existing modalities we keep aware of developing technologies and analytics through an extensive internal and external network. We work closely with histology, in vivo, clinical and MALDI Bioimaging, making use of resources available across R&D. The ability to determine the distribution of unlabelled drug related material and endogenous molecules at cellular resolutions give us the ability to address key factors for compound efficacy and safety.
Key Responsibilities include, but are not limited to:
- Delivering analysis of tissue samples using nano-flow mass spectrometry (including static nanospray and nano LC-MS/MS using Orbitrap instruments) and associated imaging techniques
- Delivering data analysis and database searching approaches to identify both small and large endogenous biological molecules (e.g MaxQuant, Proteome Discoverer, Compound Discoverer)
- Furthering the development and delivery of sampling from live cells as a defined project work package, including associated cell culture, imaging, sampling and data analytics
- Preparing samples from ex vivo tissue and in vitro cell culture for MS imaging at cellular and sub-cellular resolutions
- Working in partnership with project teams to understand project issues, provide input and report data to matrix teams, including close networking with all imaging groups across GSK.
- Maintaining timely communication to named key study personnel, other key stakeholders and management, of study related events and/or deviations
- Sharing responsibility for lab management, equipment maintenance, safety rep and similar roles
Closing Date for Applications: Tuesday 31st March 2020 (COB)
Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.
We are looking for professionals with these required skills to achieve our goals:
- BSc/MSc in biology/biochemistry discipline with relevant mass spectrometry experience
- Experience of nano flow mass spectrometry and associated techniques for analysing biological samples
- Experience of mass spectrometry data analysis and database searching to identify endogenous biological molecules.
- Evidence of effective interpersonal, organisational and communication skills for working in a multi-disciplinary scientific team environment.
If you have the following characteristics, it would be a plus:
- PhD in mass spectrometry, Biological or Biomedical Science, cell signaling or investigating biological pathways
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These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
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