Imaging Lead for Functional Genomics

Site Name: UK - Hertfordshire - Stevenage, USA - Pennsylvania - Upper Providence
Posted Date: Mar 4 2020
Why GSK?
At GSK we are poised to transform drug discovery by taking advantage of the genetic clues behind disease. Our new approach to R&D is at its core focused on the immune system, and will leverage human genetics, functional genomics and advanced analytics to improve the probability of success of developing new medicines. If you are inquisitive, creative, and bold, we need individuals like you to join us in our mission to study the basis of human disease and disrupt Healthcare.

Job Purpose:
At this time we are seeking an Imaging Lead to join our newly created Functional Genomics department within GSK R&D. This department is being built to industrialize and scale preclinical genome editing, and use a range of cellular phenotyping technologies to probe the consequences. These include high content imaging and a range of omics technologies in models ranging from single cells to 3D in vitro systems. The department not only has a strong internal basis for this work, but also capitalizes on the strengths and expertise of key external partners such as Altius, Open Targets, and the Laboratory for Genomic Research; all in an effort to help drive the best opportunities into our drug discovery pipeline.

Key Responsibilities:

  • Set the strategic direction for and lead a team of preclinical imaging scientists and data analysts to support functional genomics efforts at GSK.
  • Continuously identify opportunities to use imaging to phenotypically characterize the consequences of genetic screens being executed within the department or at one of our strategic partners.
  • Explore internal and external opportunities to advance preclinical imaging technologies and demonstrate application to pipeline relevant activities.
  • Represent the department in an internal Imaging network that spans R&D, and help to collectively optimize the use of imaging for pharmaceutical research at GSK.
  • Work with other members of the High Throughput Biology & Imaging leadership team to manage the department, develop staff, and optimize our impact on pipeline efforts.
  • Ensure the external visibility of the team by contributing to the authorship of scientific papers and presentations, and represent the department and GlaxoSmithKline at internal and external scientific meetings as needed.

Why You?
Basic Qualifications:
  • PhD in a physical or life science with 6 or more years postgraduate experience, or a Masters in the same with 10 or more years postgraduate experience.
  • Demonstrated ability to think strategically about the use of imaging.
  • Significant hands-on experience in the use and/or analysis of a range of preclinical imaging techniques.
  • A good understanding or hands on experience with deep/machine learning based analyses of cellular images.
  • Experience with or significant knowledge of the optimization of translatable cellular assays for use in preclinical drug discovery research such as 2D co-cultures, spheroids, organoids or organs-on-a-chip.
  • Practical experience or significant familiarity with automating imaging assays for scale and throughput.
  • Demonstrated ability to work in or lead multi-disciplinary matrix teams, displaying excellent interpersonal skills.
  • Strong organizational and communication skills (both written and oral), with the ability to liaise with scientists and external collaborators at all levels.

Preferred Qualifications
  • Demonstrated understanding of the current drug discovery and development process

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