Computational Biologist - Oncology

    • Collegeville, PA

Site Name: UK - Hertfordshire - Stevenage, USA - Pennsylvania - Upper Providence
Posted Date: May 12 2020
We are seeking a motivated, innovative, skilled and enthusiastic computational biology analyst to join our expanding team within the Human Genetics department. With a focus on Oncology, candidates should be keen to apply state of the art analysis methods to drive decision making across the GSK pipeline, integrating diverse and complex data types to generate biological insights that will translate into innovative new medicines for patients with unmet medical need.

At the core of GSK's R&D approach is the identification of new medicines by leveraging the vast amounts of human genetic and genomic data now being generated and applying cutting edge technologies in functional genomics and machine learning.

Within the Human Genetics team, we leverage major scientific and technological advances, including investment in biobanks linked to large-scale human health databases, cutting-edge informatics platforms and integration of biological pathway and functional genomics data to identify novel targets. We continue to evaluate these targets throughout their life in the pipeline, using genetics and genomics to identify the patients that are most likely to benefit and biomarkers to select these patients and assess efficacy.

The successful candidates will work in a multidisciplinary, collaborative and scientifically driven environment, interacting with GSK scientists and external collaborators to advance Oncology drug discovery and clinical development. This field-leading research addresses important drug discovery and development challenges, directly impacts GSK's R&D pipeline, and publishes results in top scientific journals.

Selected candidates will:

  • Develop and implement computational approaches to translate human genetic and genomic evidence to inform Oncology target selection, validation and patient stratification decisions.
  • Participate in project teams with GSK scientists and external collaborators.
  • Find creative solutions and work with agility to address challenging scientific questions.
  • Contribute to the developing science of drug target identification and validation, providing scientific expertise within Human Genetics and across the Research organisation.

Why you? Basic Qualifications:
We are looking for professionals with these required skills to achieve our goals:
  • PhD or equivalent experience in computational biology, bioinformatics, computational sciences, machine learning or biomedical engineering/biological sciences.
  • Proficient in a programming language (such as R, Python or SQL).
  • Experience with databases such as TCGA, GTEx and CCLE.
  • Experience of analysing and interpreting multi-omic data, especially RNA-Seq and single cell RNA-Seq, including data from patient samples.
  • Data science skills to collect, integrate, mine and analyse complex biological data and translate them into testable hypotheses.
  • Demonstrated skills working in teams to find creative ways to address scientific questions.
  • Strong verbal and written communication skills and developing leadership skills for working with multidisciplinary teams and with international colleagues.

Preferred Qualifications:
If you have the following characteristics, it would be a plus:

Demonstrated experience in the analysis and integration of multi-omics data (e.g. transcriptomics, regulatory genomics, proteomics) for disease research.
  • Understanding of cancer and immuno-oncology biology (pathways, mechanisms, cell types).
  • Application of pathway and network analysis methodology.
  • Pharmaceutical or biotech industry experience working on Oncology or Immuno-Oncology related projects.

#gskgenetics

Why GSK?
Our values and expectationsare at the heart of everything we do and form an important part of our culture.
These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
  • Agile and distributed decision-making - using evidence and applying judgement to balance pace, rigour and risk.
  • Managing individual and team performance.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Implementing change initiatives and leading change.
  • Sustaining energy and well-being, building resilience in teams.
  • Continuously looking for opportunities to learn, build skills and share learning both internally and externally.
  • Developing people and building a talent pipeline.
  • Translating strategy into action - a compelling narrative, motivating others, setting objectives and delegation.
  • Building strong relationships and collaboration, managing trusted stakeholder relationships internally and externally.
  • Budgeting and forecasting, commercial and financial acumen.


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GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

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