Biopharm Chemometrics and Process Modeling Expert

    • King of Prussia, PA

Site Name: USA - Pennsylvania - King of Prussia
Posted Date: Aug 11 2020
GlaxoSmithKline (GSK) is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

Biopharm Process Development is a highly experienced Chemistry, Manufacturing and Controls (CMC) organization accountable for delivering robust, cost effective and competitive products and manufacturing processes spanning the full life-cycle of asset development from Discovery through commercialization. These activities are delivered through state-of-the art internal facilities as well as strategic external partners. Collectively, the team is accountable for CMC activities encompassing cell line development, cell culture/ microbial fermentation, purification development, and drug product/ device development. We also pioneer innovative technologies to improve robustness, reduce cost of goods, and improve the patient experience.

Within Biopharm Process Development, the Microbial and Cell Culture Development department is responsible for the development of cell culture processes for the manufacture of GSK's Biopharm assets. The Department is also responsible for the scale-up and tech transfer of the processes to manufacturing facilities all over the world. Our aim is to integrate innovative expression and process platforms, automation and advanced data analytics into the upstream process development workflow. An opportunity has arisen for a chemometrician to develop and maintain key chemometric Raman models. He/she will also have the opportunity to work with our advanced data analytics team to create process models to enable process improvements, incorporate PAT such as Raman and capacitance, and develop automated workflows for data handling.

As a chemometrician, you will be a member of a highly skilled team of scientists and engineers responsible for the evaluation and optimization of cell culture processes. You will be responsible for developing and maintaining key Raman chemometric models that are utilized to monitor and control key aspects of the bioreactor process. You will also engage with other groups within GSK to progress the application of process models in development and GMP space. Although predominantly lab-based, the role also involves important aspects of verbal and written communication and requires good organisation skills as well as a broader scientific knowledge. Both individual and team working are required and therefore the role will suit a scientist with good interpersonal skills, ability to solve complex problems, self-motivated and has an open mindset.

This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following...

  • Development and maintenance of PAT (such as Raman, Capacitance, FTIR) chemometric models.
  • Providing guidance on the design of experiments to collect data for the development of chemometric models.
  • Applying statistical analysis and advanced data analytics to gain process understanding and improvement.
  • Contributing to the adoption of the modeling and PAT strategy for new products and processes and the validation packages to meet regulatory requirments.
  • Staying current with new modeling techniques through publications, conferences and academic and precompetitive collaborations
  • Presenting data and status reports to senior management.

Why you? Basic Qualifications:
We are looking for professionals with these required skills to achieve our goals:
  • PhD in Chemometrics, Chemical Engineering or a related subject with emphasis on data analytics and process modeling
  • Experience with bioprocesses, process monitoring and control, data science, and data analytics

Preferred Qualifications:
If you have the following characteristics, it would be a plus:
  • Ability to multi-task and manage workload independently
  • Proven track record of applying mathematical modeling approaches to bring value to business
  • Demonstrated ability to independently design and execute work plans to support model development
  • Capability to enable strategic approaches to drive maturity of analytics from a business case standpoint
  • Ability to work within a team and communicate effectively
  • Demonstrated ability to create chemometric and mathematical models from wide variety of PAT/spectroscopy data
  • Good interpersonal, organizational and communication skills
  • Application of mainstream chemometric techniques (multivariate classification, calibration, pattern recognition, PCA/PLS) and familiarity with design of experiments concepts and methods
  • Experience in the use of advanced chemometric methods for process modeling (MSPC, MCR) and 'data wrangling' for signal processing and feature extraction.
  • Familiarity with other data driven machine learning methods (SVM, ANN, Bayesian modeling) or the application of hybrid empirical/mechanistic modeling
  • Industrial experience in one or more of the following areas: i) continuous processes; ii) biopharmaceuticals development; iii) product industrialisation and manufacturing
  • Programming experience using languages such as MATLAB, SIMCA, CAMO Analytics, Python, R or C etc

Why GSK?
Our values and expectations are at the heart of everything we do and form an important part of our culture.
These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

  • Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being.
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness.

*LI-GSK
gskbiopharm_development

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