Antibody Discovery B-cell Scientist
- Stevenage, United Kingdom
Site Name: UK - Hertfordshire - Stevenage
Posted Date: Dec 9 2020
GlaxoSmithKline (GSK) is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.
The Biopharm (BP) Unit is at the heart of GSKs ambition to deliver antibody and other biopharmaceutical medicines. The BP Unit has the remit to design and optimize biopharmaceuticals from Target to Candidate Molecule exploiting cutting edge technology and delivering diverse lead panels from which high-quality candidates can be selected and seamlessly transferred to Biopharmaceutical Product Development and Supply.
Within BP the Antibody Selections (AS) group has responsibility for identifying high quality hits and leads from library and in vivo technologies and deliver an important contribution to GSKs Biopharm pipeline. The AS team uses multiple antibody discovery platforms (yeast display, in-vivo immunisation and phage display) to generate diverse panels of antibodies to therapeutic targets, which are expressed and triaged using a variety of characterisation assays.
We also work with external groups to deliver monoclonal antibody reagents for therapeutic and tool applications. In addition, the Antibody Selections group has accountability for developing and implementing new antibody discovery technologies to enable discovery increasingly diverse antibody panels and generation of therapeutic candidates against challenging targets.
The Antibody Selections group has an exciting opening for a highly skilled and experienced scientist. You will be part of the in-vivo antibody discovery team in AS and will utilise your skills and experience to enable the discovery of high-quality antibodies using B-cell screening. Using our human antibody transgenic mouse, you will be involved in the design and execution of antibody discovery campaigns for therapeutic targets. In addition, you will look for opportunities to further optimise this process from immunisation to B-cell screening to improve quantity and quality of the antigen specific B-cells that are isolated.
Key Responsibilities include, but are not limited to:
- Scientific leadership and impact through a lab-based role.
- Accountable for delivery of high-quality hits and leads to program teams using our in vivo antibody discovery platforms
- Optimisation of staining, isolation and FACS sorting of antigen specific B-cells
- Work effectively within multidisciplinary teams
- Maintaining high quality and accurate records of data in GSK databases and electronic lab notebooks.
- Generate and interpret process performance data from in-vivo antibody discovery campaigns
- Clear and concise presentations of results to peers and project teams.
We are looking for professionals with these required skills to achieve our goals:
- Expert with extensive experience in the staining and fluorescence activated cell sorting (FACS) of mouse immune cells using multiple colours
- Deep Knowledge of murine B-cell biology and immunology for isolation of optimal cell populations for antigen specific B-cell sorting
- A PhD in relevant subjects (murine immunology, murine B-cell biology, in-vivo antibody discovery) or equivalent experience.
- Demonstrated ability to work effectively in multi-disciplinary teams and will display excellent interpersonal and communication skills.
- Previous experience of sorting murine antigen specific B cells isolation would be an advantage.
- Additional experience of using microfluidics systems for isolating and sorting of antigen specific B-cells would be an advantage.
If you have the following characteristics, it would be a plus:
- Knowledge of single B cell PCR and V region cloning/engineering and expression would be advantageous.
Our values and expectationsare at the heart of everything we do and form an important part of our culture.
These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
- Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
- Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
- Continuously looking for opportunities to learn, build skills and share learning.
- Sustaining energy and well-being.
- Building strong relationships and collaboration, honest and open conversations.
- Budgeting and cost-consciousness.
As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers. As a candidate for a role, we want you to feel the same way.
As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class(US only).
We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
Please don't hesitate to contact us if you'd like to discuss any adjustments to our process which might help you demonstrate your strengths and capabilities. You can either call us on 0808 234 4391, or send an email email@example.com
As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.
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