Senior Scientist

Your Responsibilities:
Responsibilities may include:
• Contribute, as a member of a multi-discipline team, to the design of an efficient clinical development program and a robust registration package
• Play a central role in predicting human dose range, characterizing dose-response relationship and justifying dose recommendations for special population
• Develop mathematical and statistical models to understand a disease, its progression, and pharmacodynamics and pharmacokinetics; conduct meta-analyses as appropriate to maximize data use; conduct simulations to assess trial design performance
• Design and interpret clinical pharmacology studies, including those to evaluate potential effects of intrinsic and extrinsic factors on pharmacokinetics and pharmacodynamics
• Write sections of drug development and registration documents such as clinical trial protocols and reports, clinical investigator brochures and regulatory submission packages
• Present and defend quantitative clinical pharmacology plans and results through interaction and negotiation with internal governance committees and external regulators
• Innovate through working effectively with colleagues in the department and others such as statisticians, biologists, physicians and drug metabolism scientists
• Learn and apply emerging modelling and simulation methodologies with a view to enhance clinical program efficiency and investment decision quality; collaborate with external field-leading teams for methodology application
• Promote model-informed drug development approach by publishing in peer-reviewed journals and presenting at scientific conferences

Why You?

Basic qualifications:
• Advanced training with a degr• Advanced training with a degree such as PhD, PharmD and MD to enable a successful career in quantitative clinical pharmacology in pharmaceutical research and development
• Experience in designing, analyzing and reporting clinical studies, with a simulation- or modelling-based approach where appropriate
• Ability to communicate clearly and succinctly with the audience in mind, both orally and in writing
• Sound judgement, analytical mindset and problem-solving skills
• Ability to effectively multi-task and deliver results on time

Preferred qualifications:
• Knowledge of or ability to quickly learn the mechanism, endpoints, progression and treatments of relevant diseases
• Understanding of pharmacokinetic and pharmacodynamic principles and commonly applied models; working knowledge of common tools for quantitative clinical pharmacology such as NONMEM, R, WINNONLIN, Simcyp, SAS and MATLAB
• Familiarity with regulatory submission documents such as CTAs, INDs, NDAs, MAAs and BLAs
• Ability to build effective collaboration while taking personal accountability for delivery of quantitative clinical pharmacology results

*LI-GSK

Why GSK?:
At GSK, our mission is to improve the quality of human life by enabling people to do more, feel better and live longer. Our three world-leading businesses research and deliver innovative medicines, vaccines and consumer healthcare products. We need a talented and motivated workforce to deliver against our strategy. To achieve this, we strive to attract the best people and to create an environment that empowers and inspires.

Contact information:
You may apply for this position online by selecting the Apply now button.
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