Postdoctoral Fellow, GSK Immunology Catalyst

Your Responsibilities:
An exciting opportunity has arisen for a postdoctoral fellow to join GSK's Immunology Catalyst training programme. This is a temporary position for up to two years.
Post-doctoral fellows within GSK's Immunology Catalyst programme have the opportunity to:
• Be part of a unique network of immunologists working to discover the next breakthroughs in immunology. This network includes the group leaders in the Catalyst (high achieving PI's on sabbatical at GSK), leading immunologists at GSK and world class immunologists on the external immunology board.
• Be part of cutting edge science to advance GSK's mission 'to improving the quality of human life by enabling people to do more, feel better, and live longer'.
• Accelerate your post-doctoral research with GSK's extensive R&D engine.
• Bridge the gap from target identification to medicine for patients in need by leveraging GSK's tools, technologies, libraries, samples, people, knowledge base, & training programme.

The postdoctoral research projects are focused on addressing basic immunology questions and are under the supervision of academic experts who are members of the Immunology Catalyst. These mentors will be focused on providing a comprehensive training program and are expected to nurture skills that will enable postdocs to become independent scientific investigators. Catalyst members have been selected based on their cutting edge immunology expertise and projects in this programme are in ground-breaking areas of science for post-doctoral training, as defined by the catalyst and external immunology board members.

This role will be located in Stevenage, UK working with Dr Florent Ginhoux, who is on secondment from the Singapore Immunology Network (SIgN), ASTAR. The project will be focused on 'Unravelling new molecular checkpoints of DC and monocyte/macrophage lineage commitment.'
Monocytes and monocyte-derived cells (MC) that have features of both tissue dendritic cells and macrophages play important roles in tissue homeostasis and immunity, but also contribute to inflammation and are thus attractive therapeutic targets. Potential intervention strategies aimed at manipulation of these cells will require in-depth insights of their origins and the mechanisms that govern their homeostasis.

The project aims to map out the developmental pathway of these cells and to study how these pathways are affected in disease. Molecular checkpoints of lineage commitment that are identified will be targeted with defined compounds from GSK libraries. Complementary approaches of RNA sequencing and epigenetic profiling of the different stages of differentiation will also be employed.

These new insights into the differentiation of monocyte/MC should aid the rational design of therapies aimed at harnessing the functions of these cells in homeostasis and inflammation and will allow efficient targeting and manipulation during health and disease.

Your Postdoctoral experience will be accompanied by tremendous support at GSK with the opportunity for daily collaboration with world-class scientists.

You will be actively encouraged to publish and present your research at internal and external meetings and participate in the GSK R&D postdoc community, which will include scientific and social programming.

Please use the cover letter to highlight how you meet the skills and competencies for the role. Your cover letter and CV will be used to assess your application.

Closing date for applications: 25th October 2018


Why You?

Basic qualifications:
- PhD. degree in Immunology or related field (microbiology, genetics, biochemistry, medicine, etc.)
- Strong knowledge and practical execution of flow cytometry sample preparation and data analysis
- Experience in and the ability to understand, interpret and communicate complex scientific data; be comfortable conversing with opinion leaders regarding highly technical information
- A self-starter, able to handle multiple projects concurrently
- Possess a good balance of creative, analytical and strong communication skills
- Experience of being productive and successful in a work environment
- An effective team player

Preferred qualifications:
- Cell biology experience including blood cell isolation

Why GSK?:
At GSK, our mission is to improve the quality of human life by enabling people to do more, feel better and live longer. Our three world-leading businesses research and deliver innovative medicines, vaccines and consumer healthcare products. We need a talented and motivated workforce to deliver against our strategy. To achieve this, we strive to attract the best people and to create an environment that empowers and inspires.

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process.

If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements, please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process

Contact information:
You may apply for this position online by selecting the Apply now button.
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