Investigator - Upstream Process Development
GSK currently have three opportunities for Investigator level scientists to join our Upstream Process Development Group.
The candidates will be part of the Microbial and Cell Culture Department responsible for the upstream development of early and late phase processes for the production of therapeutic proteins. Work packages may include execution of small scale bioreactor studies for evaluation and/or optimization of processes for improved facility fit, small scale model qualification, optimization of chemically defined media/feed platforms, ATF/perfusion implementation and the evaluation of new technologies.
They will be responsible for process scale-up and technology transfer of biopharm assets for the production of clinical supplies. The candidate will represent the department on project teams. The candidate will be responsible for authoring technical reports, technology transfer documents, and CMC sections for regulatory filings. The candidate will be expected to interact on a routine basis with colleagues in downstream process development, analytical methods development, clinical manufacturing groups.
Ph.D. in Bioprocess/Biochemical/Chemical Engineering or related Biological Sciences with 1 to 3 yrs of industrial experience or B.S./M.S. in Bioprocess/Biochemical Engineering/Chemical or related Biological Sciences with >7 yrs of industrial experience.
The candidate should have a demonstrated record of scientific achievement and a broad integrated knowledge of mammalian cell culture process optimization, and small scale bioreactors. Basic knowledge of statistical analysis and project management is highly desired. Prior experience with bioreactor operation is a plus.
The candidate must be a highly motivated self-starter, with excellent verbal and written communication skills, and the ability to work effectively in team and matrix environments.
The preferred candiate will have hands on experience in the development of mammalian cell culture processes for the manufacture of protein theraputics. Previous experience with process scale-up/transfer and authoring of CMC sections for regulatory filings is preferred.
Candidate must have good understanding of chemically defined cell culture media/feeds impact on recombinant protein productivity and product quality. Knowledge of PAT principles and equipment concomitant with the statistics (eg multivariate analysis or PCA, chemometrics) necessary to advance new technologies is a plus as well as experience with automation and ability to handle and analyze large data sets.
At GSK, our mission is to improve the quality of human life by enabling people to do more, feel better and live longer. Our three world-leading businesses research and deliver innovative medicines, vaccines and consumer healthcare products. We need a talented and motivated workforce to deliver against our strategy. To achieve this, we strive to attract the best people and to create an environment that empowers and inspires.
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