Investigator– DMPK, Mechanistic ADME

Basic qualifications:

  • PhD degree in medicinal chemistry, pharmaceutical sciences, or related areas with strong knowledge of drug transporters and pharmacokinetics.
  • Sufficient level of expertise of transporters and/or drug metabolizing enzymes and the role they play in drug disposition and safety.
  • Good knowledge of mechanistic understanding for drug-drug interaction (DDI) and ability to predict DDI risk using in silico tools as well as physiologically-based pharmacokinetic (PBPK) model simulation (simCYP or other platforms).

Preferred qualifications:

  • Pharmaceutical industry working experience, knowledge in HIV therapeutic area as additional strength.
  • Deep expertise in in vitro- in vivo extrapolation, DDI risk assessment at different drug development phases, and/or strong PBPK modeling skills.
  • Working experience in pre-clinical drug development environment, in-depth understanding of drug ADME mechanism and translation of safety risks to the clinic.
  • Track record of scientific achievement.
  • Demonstrated ability to work effectively in a team environment and across departments and good communication and writing skills.


Provide expertise and recommendations to project representatives and/or project teams to support optimal delivery of mechanistic ADME data and to ensure patient's safety by sufficient risk assessment towards drug transporter characterization, metabolic pathways and DDI prediction

Key Responsibilities:

  • Responsible for supporting DMPK project representatives and/or project teams to deliver ADME data and to provide risk assessment towards drug biotransformation, transporters and DDI, especially for projects and/or programs in HIV therapeutic area.
  • Responsible for coaching junior scientists to execute studies in in vitro ADME studies, DDI risk assessment, and to trouble shoot experimental issues.
  • Responsible for delivering high quality study reports, publications, and regulatory dossiers to support drug development.
  • LI-GSK

Contact information:

You may apply for this position online by selecting the Apply now button.

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