Investigator, Developmental Chemistry

Your Responsibilities:
DNA-Encoded Library Technology (ELT) is a drug discovery platform that provides access to broad chemical diversity through affinity selections.

The success of ELT relies heavily on the collection of DNA-Encoded Libraries (DELs), and on this front we are seeking a chemist that will contribute to DNA-compatible reaction development, DEL design and synthesis, and other aspects of ELT chemistry.

In addition to expertise in synthetic organic chemistry, we will also be looking for a candidate that displays excellent communication, collaboration and leadership skills/potential.

For further information see the following references:

Clark et al. Design, Synthesis and Selection of DNA-Encoded Small-Molecule Libraries. Nat. Chem. Biol. 2009, 5, 647-654.

Arico-Muendel. From haystack to needle: finding value with DNA encoded library technology at GSK. MedChemComm 2016, 7, 1898-1909. DOI:10.1039/c6md00341A

Machutta & Kollmann et al. Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening. Nat. Commun. 2017, 8, 16081. DOI:10.1038/ncomms16081

Why You?

Basic qualifications:
• PhD in organic or medicinal chemistry, or related academic fields
• Knowledgeable in the application of new synthetic methodology and high level of synthetic chemistry expertise.
• High level of scientific credibility as demonstrated through peer-reviewed publications, presentations, and/or patents.

Preferred qualifications:
• 3+ years of professional and/or industrial experience
• Familiar with DNA-encoded library technology (ELT) platforms being used in academic, biotech and pharmaceutical companies.
• Experience in development and/or application of bioconjugation chemistry, DNA-compatible chemistry, parallel solution phase chemistry and/or solid support chemistry.
• Experience in automated chemistry platforms and informatics tools for managing large data sets.
• Basic understanding of the early stage aspects of medicinal chemistry and the importance of compound quality (MW, cLogP, etc.).
• Examples of proposing and exploring new chemistry strategies (reaction development, synthetic routes, etc.).
• Highly organized and flexible in role assignments with solid written and oral communication skills.
• Must be able to work effectively in a matrix team environment.
• Must demonstrate the ability to review scientific data critically and communicate these findings effectively.
• Experienced in maintaining detailed records and good capacity to comprehend scientific literature.

Why GSK?:
Today there are still millions of people without access to basic healthcare, thousands of diseases without adequate treatments and millions more people who suffer from everyday ailments. At GSK we want to change this.

We want to help people do more, feel better, live longer

We have three world-leading businesses that research, develop and manufacture innovative pharmaceutical medicines, vaccines and consumer healthcare products.

Across the US, we employ more than 15,000 people who strive to help others do more, feel better and live longer. This work starts one person, one community, and one story at a time.

As a science-led, global healthcare business with clear values, we offer countless opportunities for people at various stages of their careers. On-the-job learning and rewarding individual contributions are extremely important to us. We believe in creating an inclusive and safe working environment and supporting our employees to help their communities.


Contact information:
You may apply for this position online by selecting the Apply now button.
If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK HR Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.

Meet Some of GlaxoSmithKline's Employees


Procurement Associate

Jasdeep finds diverse suppliers to build GSK’s pipeline. He organizes joint ventures with companies and negotiates pricing rates and payments to build a seamless supply system for GSK’s materials and products.


HR Associate, Future Leaders Program

Now in her second rotation of GSK’s Human Resources Future Leaders Programme, Andrea is shaping the future of talent management within Research and Development, from workforce assessments to strategy and operations.

Back to top