Associate Scientist, Vector Process Development

Your Responsibilities:
GlaxoSmithKline (GSK) is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery for strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

GSK's Cell & Gene Therapy Platform CMC team is being expanded to support an increasing portfolio of cell and gene therapies. The team is responsible for delivering the Chemistry, Manufacturing and Controls (CMC) aspects of the projects from early phase to launch and the development of innovative technologies to enable step-change improvements to cell & gene therapy manufacture.

GSK has a significant collaboration in the T cell immunotherapy field with Adaptimmune and other licensing/partnership opportunities are being pursued. The progression of our own portfolio together with the maturation of emerging gene therapy technologies creates an imperative for GSK to now increase our investment in this space and establish an end to end leading platform. This will facilitate delivery of the portfolio in Oncology as well as ensuring that GSK is able to capture the potential of the emerging technologies in other therapeutic areas.

A highly motivated, independent individual with a desire to learn and develop their experience of process development is sought to work within this team. Your duties will include and are not limited to:

• Working collaboratively with Cell & Gene Therapy Platform CMC vector, upstream, analytical and cell process development scientists to establish robust downstream processes, for the production of viral vectors (lenti and AAV).
• Define and execute experimental strategies to establish a lentivirus production platform including in-process testing/controls delivering high lentivirus titres and recoveries whilst maintaining product quality.
• Contribute to the definition and delivery of process development programmes outsourced to external Contract Manufacturing Organisations.
• Define, develop and validate innovative technologies and approaches to make step changes in lentivirus expression, recovery/purification efficiency or analysis.
• Support development of a portfolio of ex-vivo gene therapies from early to late stage by providing input to project teams, directing development work, reviewing data and supporting regulatory interactions.
• Maintain awareness of external technology and patent landscape, as well as competitor process technology activity

Why You?

Basic qualifications:
• BSc or MSc in Biochemistry or other Life Sciences related discipline.
• Experience with working in a lab environment and performing standard cell culture or biochemistry techniques.
• Basic knowledge of common unit operations used in upstream and downstream processing.
• Basic knowledge of in process analytical methods or assay development.

Preferred qualifications:
• Experience of upstream or downstream process development for viral vectors, biopharmaceuticals or vaccines. As well as the willingness to learn about viral vector expression, purification and scale up as well as the required in process analytical methods.
• Experienced of optimisation and scale up of upstream or downstream processes for the production of clinical grade lentivirus, adeno-associated virus (AAV) or other biomolecules.
• Experience of cell culture, protein purification or assay development.

Why GSK?:
At GSK, our mission is to improve the quality of human life by enabling people to do more, feel better and live longer. Our three world-leading businesses research and deliver innovative medicines, vaccines and consumer healthcare products. We need a talented and motivated workforce to deliver against our strategy. To achieve this, we strive to attract the best people and to create an environment that empowers and inspires.

Contact information:
You may apply for this position online by selecting the Apply now button.
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