Postdoctoral Fellow - Diamond lab

Requisition ID: 6171

Job Title: Postdoctoral Fellow – Diamond lab – Pre-clinical Development and Evaluation of Cancer Therapeutics.

Summary:

To work independently in a team environment devoted to the development and evaluation of biological-based immunotherapeutic approaches that target and eliminate solid or hematopoietic malignancies in pre-clinical models of cancer. The aim of this research is to develop methods to deliver vaccines and immunotherapeutics in order to induce or enhance long-term anti-tumor responses. The overall goal of these pre-clinical studies will be to provide supporting data for the potential clinical translation of novel, effective therapeutic approaches. See these publications for examples of approaches used for preclinical studies:

Blache CA, Manuel ER, Kaltcheva TI, Wong AN, Ellenhorn JDI, Blazar BR, and Diamond DJ. Systemic Delivery of Salmonella Typhimurium Transformed with IDO shRNA Enhances Intratumoral Vector Colonization and Suppresses Tumor Growth. Cancer Res. 72:6447-6456, 2012. PMC3525777

Hardwick N, Carrol M, Kaltcheva T, Qian D, Lim D, Leong L, Chu P, Kim J, Chao J, Fakih M, Yen Y, Espenschied J, Ellenhorn DI, Diamond DJ, Chung V. p53MVA therapy in patients with refractory gastrointestinal malignancies elevates p53-specific CD8+ T cell responses. Clin Cancer Res. 20:4459-4470, 2014. PMC4155000

Manuel ER, Chen J, D’Apuzzo M, Lampa MG, Kaltcheva TI, Thompson CB, Ludwig T, Chung V, Diamond DJ. Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Coupled with Enzymatic Depletion of Tumor Hyaluronan Induces Complete Regression of Aggressive Pancreatic Tumors. Cancer Immunol Res. 3(9):1096-1107, 2015. PMID:26134178

Israyelyan A, Goldstein L, Tsai W, Aquino L, Forman SJ, Nakamura R, Diamond DJ. Real-time assessment of relapse risk based on the WT1 marker in leukemia and MDS patients after hematopoietic cell transplantation. Bone Marrow Transpl, 50(1):26-33, 2015. PMC:4286541

Minimum Education and Skills Required for Consideration:

Ph.D. in oncology, biochemistry, immunology, microbiology with an emphasis in cancer. Mouse handling with proficiency in different routes of injection is required. Strong critical thinking skills and ability to troubleshoot. Experience in molecular techniques such as cloning, tissue and bacterial culture methods, and tumor tissue processing. Strong command of the English language with the capacity to write and speak scientifically. Should be able to work effectively in a team environment, be self-motivated, productive, and require little to no supervision once trained. Please include CV with publication record and (if applicable) grant funding.

About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 4000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy. Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s 20 leading cancer centers that develops and institutes standards of care for cancer treatment.

City of Hope is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color national origin, sex, age, status as a protected veteran, or status as a qualified individual with disability. *LI-AP


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