Postdoctoral Fellow - Cellular Interactions Between Oncogene and Tumor Suppressor Signaling- Singhal lab

A Postdoctoral Fellow position is available in the laboratory of Dr. Sharad Singhal at the Beckman Research Institute of the City of Hope. The Beckman Research Institute is an innovative biomedical research, treatment and educational institution, and a designated Comprehensive Cancer Center by the National Cancer Institute. The City of Hope’s Beckman Research Institute provides an environment that encourages interdisciplinary collaboration. The candidate should have strong experience in carcinogenesis and metastases studies with a good focus on the key factors influencing the cellular interactions between oncogene and tumor suppressor signaling. Experience in animal models of cancer is essential. Doctoral degree in biological sciences is required.

Key Responsibilities

  • Perform cell viability, carcinogenesis and metastases assays in vitro to assess the activity of novel cancer agents and combinations. Experience in molecular biology techniques to assess tumor suppressor and oncogene activities is desired. Expertise with methylation studies is a plus.
  • Perform antisense and antibody studies in single and combination with natural compounds to assess carcinogenic and chemopreventive activities, in-vivo.
  • Perform carcinogenesis and biomarker studies in xenograft and transgenic mice models.
  • Make summary of results for regular laboratory meetings. Actively discuss with mentor/PI on the progress of project goals.
  • Good critical thinking and writing skills to contribute towards manuscripts, poster and conference presentations.
  • The candidate should have expertise in major areas discussed above and should be willing to actively incorporate new strategies/techniques as per the goals of projects.

Minimum Education and Skills Required for Consideration:

  • The candidate should have completed PhD in Biological Sciences with significant research accomplishments.
  • Experience in developmental therapies with a focus on investigative cancer drugs as well as natural products.Experience in drug combinations, chemical carcinogenesis, chemoprevention, and metastases studies are essential.
  • Candidate should have significant experience working in animal models of cancer.
  • Attention to details, willingness to learn new techniques and critical thinking skills as essential to rapidly integrate clinical-translational inputs from PI/mentors into investigative procedures to contribute to initiation and progress of projects in developmental cancer therapies.

About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 4000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy. Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s 20 leading cancer centers that develops and institutes standards of care for cancer treatment.

City of Hope is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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