Postdoctoral Fellow - Cancer Genetics
- Duarte, CA
About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.
Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s leading cancer centers that develops and institutes standards of care for cancer treatment.
Postdoctoral positions are now available in the laboratory of Dr. Yilun Liu at the Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope. Dr. Liu’s research focus relates to (1) dissecting the mechanism by which cells prevent the formation of endogenous DNA breaks as a consequence of unresolved collision between a replication fork and a transcription machinery or a transcription-induced R-loop; (2) developing pharmaceutical mechanisms for cancer therapy by targeting enzymes important for resolving R-loops or transcription-replication collisions to enhance DNA break formation as well as factors important for the BRCA2 and PARP-dependent repair pathways to keep these DNA breaks unrepaired; and (3) targeting mitochondrial DNA as signaling molecule in immune response and cancer therapy.
Basic education, experience and skills required for consideration:
- A Ph.D. degree in life or biomedical sciences, or a related discipline is required.
- Experience in biochemistry and/or cell biology is preferred
- For more information on Dr. Yilun Liu’s research please visit, here .
- Dr. Liu’s group has published in journals, including Nature Communications, Cell Reports, EMBO Journal and PNAS. A full list of publications can be found here .
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