A Postdoctoral Fellow position is available in the laboratory of Leo Wang, MD, PhD, at City of Hope, Duarte, CA.
The lab’s research in the Department of Immuno-oncology uses small-scale mass spectrometry to identify posttranslational modifications that are important in blood stem and progenitor cell biology, using rare populations isolated from patients and animals. The lab uses these novel findings to expand our knowledge of how stem and progenitor cells develop, grow, and function at a protein level, and uses that knowledge to devise new therapies for cancer and blood disorders. This position will focus on molecular and cellular cancer biology, using cell culture and in vivo model systems to validate and interrogate new pathways critical to blood and leukemia stem cell survival and maintenance.
Creativity, initiative, and persistence will be absolutely essential characteristics for the successful candidate. Additionally, we are looking for enthusiastic, self-motivated individuals who thrive in a fast-paced challenging start-up research environment, and can multitask and interact well with others as part of a cohesive team. If you have the desire to make a significant impact in patients’ lives, the drive to work hard, and the ingenuity to work smart, you will succeed within this team.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
- Design, execute, keep records on, synthesize and present data from complex experiments using animal models, cell culture, and patient samples.
- Record data and analyze results using industry standard application suites.
- Maintain accurate and detailed records of experimental design and methods as well as experimental results.
- Maintain repositories of reagents, animals, and biological materials.
- Design, implement, maintain, and complete collaborations with other research groups, both locally and nationally.
- Help to prepare presentations and written articles for publication.
- Prepare laboratory reagents, chemicals, instruments, and maintain equipment.
- Maintain operations and supplies inventory in accordance with departmental procedures.
- There will likely be some travel to other research labs for collaborations, trainings, & operational expansion.
- Experience with or willingness to learn cross-discipline techniques such as mass spectrometry, mass cytometry, and/or bioinformatics is highly desired, although the primary focus will be molecular/cellular biology with a focus on cancer and immune development.
Minimum Education and Skills Required for Consideration:
QUALIFICATIONS AND REQUIREMENTS:
- Ph.D. or equivalent in cancer biology, developmental biology, or immunology required.
- Experience with cell culture, flow cytometry, molecular biology, genome editing, and in vitro work is required.
- Extensive experience working with mouse models is also essential, including working with immunocompromised stem cell transplant recipient mice.
- Ideal candidates will be self-motivated and have ambitions to further develop their scientific and career skills.They will have a desire to be challenged and to learn and create new scientific strategies.
- In addition to competitive compensation and benefits, candidates will have the opportunity to learn and develop research publications and presentations. Effective candidates will be expected to develop independent projects over time.
SKILLS / ABILITIES / COMPETENCIES REQUIRED:
- Ability to work productively and develop cohesive team relationships
- Extensive prior flow cytometry experience
- Extensive prior cancer biology experience
- Extensive prior molecular and cellular biology experience
- Background in leukemogenesis, hematopoiesis, or developmental immunology preferred
- High degree of computer literacy in Mac/PC/Linux based OS environments; R experience useful
- Good oral and written communication skills
- Must be able to logically and effectively structure tasks and set priorities
- Must be able to respond effectively to constructive feedback
- Demonstrated ability to analyze data statistically and to present it logically
- Energy, enthusiasm, and a positive outlook
Laboratory environment: Candidates will receive training in the safe handling of toxic chemicals, biohazards, animals, and substances emitting unpleasant odors. Candidates may also occasionally work with emitters of radiation.
About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 4000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy. Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s 20 leading cancer centers that develops and institutes standards of care for cancer treatment.
City of Hope is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.
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