A Postdoctoral Fellow position is available in the laboratory of Leo Wang, MD, PhD, at City of Hope, Duarte, CA.
The lab’s research in the Department of Immuno-oncology focuses on using small-scale multidimensional online liquid chromatography coupled to tandem mass spectrometry to identify activated protein circuits in rare stem and progenitor cell populations isolated from patients and animals. Using that knowledge to devise new therapies for cancer and blood disorders. This position will spend a significant amount of time in the mass spectrometry core at the Beckman Research Institute, working closely with Dr. Markus Kalkum’s group to set up and troubleshoot a small-scale 3D-LC system.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
- Design, implement, and troubleshoot an innovative small-scale 3D LC-MS system to profile small numbers of cells, based on this model: https://www.ncbi.nlm.nih.gov/pubmed/27365422
- Maintain and operate LC and MS systems in close coordination with the City of Hope mass spectrometry core facility.
- Record data and analyze results using industry standard application suites.
- Maintain accurate and detailed records of experimental design and methods as well as experimental results.
- Maintain and perform experiments with cells in tissue culture.
- Help to prepare presentations and written articles for publication.
- Prepare laboratory reagents, chemicals, instruments, and maintain equipment.
- Maintain operations and supplies inventory in accordance with departmental procedures.
- There will likely be some travel to other research labs for collaborations, trainings, & operational expansion.
- Experience with or willingness to learn cross-discipline techniques such as tissue culture, flow cytometry, animal handling, and/or bioinformatics is highly desired, although the primary focus will be mass spectrometry and liquid chromatography expertise.
Minimum Education and Skills Required for Consideration:
QUALIFICATIONS AND REQUIREMENTS:
- Ph.D. or equivalent in protein biochemistry or analytical chemistry required.
- Expertise with mass spectrometry, particularly Orbitrap systems, is essential.
- Experience customizing chromatography systems is also required, as extensive customization will be needed.
- Ideal candidates will be self-motivated and have ambitions to further develop their scientific and career skills. They will have a desire to be challenged and to learn and create new scientific strategies.
- In addition to competitive compensation and benefits, candidates will have the opportunity to learn and develop research publications and presentations. Effective candidates will be expected to develop independent projects over time.
SKILLS / ABILITIES / COMPETENCIES REQUIRED:
Creativity, initiative, and persistence will be absolutely essential characteristics for the successful candidate. Additionally, we are looking for enthusiastic, self-motivated individuals who thrive in a fast-paced challenging start-up research environment, and can multitask and interact well with others as part of a cohesive team. If you have the desire to make a significant impact in patients’ lives, the drive to work hard, and the ingenuity to work smart, you will succeed within this team.
- Ability to work productively and develop cohesive team relationships
- Extensive prior mass spectrometry experience
- Extensive prior LC experience
- Basic molecular biology and cell culture experience
- High degree of computer literacy in Mac/PC/Linux based OS environments
- Good oral and written communication skills
- Must be able to logically and effectively structure tasks and set priorities
- Must be able to respond effectively to constructive feedback
- Demonstrated ability to analyze data statistically and to present it logically
- Energy, enthusiasm, and a positive outlook
Laboratory environment: Candidates will receive training in the safe handling of toxic chemicals, biohazards, animals, and substances emitting unpleasant odors. Candidates may also occasionally work with emitters of radiation.
http://www.cityofhope.org/careers/, Job ID Number: 8375
About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 4000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy. Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s 20 leading cancer centers that develops and institutes standards of care for cancer treatment.
City of Hope is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.
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