Director, Cytogenetics

    • Duarte, CA

About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary
Provide direction and leadership for the administrative, fiscal, technical and scientific responsibilities of the Department of Cytogenetics. Ensure safe and efficient operation of the department’s major focal programs: clinical diagnostic services, laboratory-based research and development projects, translational research, and the cytogenetics shared resources core facility. Provide consultative services at an institutional level to departments, divisions, committees, Medical Center and BRI scientists, as well as outside researchers or institutions through the CCSG-grant funded shared resources core facility. Provide analysis, testing recommendations to aid in diagnoses and patient management. Provide project management details relating to work flow, facilities, publishing, regulatory and grant information needs. This position is directly accountable to the Executive Director of Pathology Laboratories within the Medical Center, and the Chair of Pathology, and may work in conjunction with a Co-Director. The Director(s) has authority and responsibility for the division of Cytogenetics. In the event of Co-Directors, essential functions are the responsibility of both Directors, but the Executive Director of Clinical Laboratories shall designate which Director will focus more attention on specific essential functions.

Key Responsibilities include:
Must have knowledge of system analysis, project management, computer software, time management, and institutional best practices, as they relate to the field of cancer cytogenetics.
Major responsibilities include:
1) Reviews, writes and interprets cytogenetic and molecular cytogenetic/cytogenomic laboratory results; communicates final report to medical staff.
2) Selects, implements, and develops departmental procedures; maintains licensure, and constant state of readiness for all unannounced State, CAP, Joint Commission, and other regulatory inspections.
3) Maintain and fosters fiscal strength of the division by improving efficiency, developing new clinical assays, and increasing revenue-producing tests.
4) Initiates and oversees validation studies for new cytogenetic and molecular cytogenetic laboratory testing options.
5) Participates in a productive translational research program within the department of Pathology and provides cytogenetic services for cancer center scientists via the cytogenetics shared resources core facility.
Clinical Service

  • Review, interpret, and finalize cytogenetic, molecular cytogenetic (FISH), and microarray laboratory results. Communicate final genetic diagnosis, written in International System for Human Cytogenetic Nomenclature (ISCN), with understandable interpretation to medical staff.
  • Provide patients with best practice cytogenetic testing by designing efficient workflow. Evaluate processing and completeness per patient study. Determine if additional assays are needed. Ensure the physicians understand why additional testing or the need to cancel a study is recommended. Request staff to obtain documentation of approval from physician if additional charges will be incurred.
  • Respond to physician inquiries relating to all aspects of cytogenetics and patient management decisions.
  • Coordinates laboratory services and processes for outreach consult testing.
  • Provides cytogenetics training rotation for Pathology fellows, as well as other medical staff fellows upon request, and oversees CA-state approved Cytogenetic Technologist training program.
Laboratory Quality Management
  • Ensures compliance with all applicable governmental and accrediting agencies’ standards.
  • Reviews of College of American Pathology (CAP) regulations and Policy and Procedure manuals annually; monthly review of QA, QC and PI records to recognize factors that affect measurements and results and take appropriate corrective action, if needed.
  • Oversees new processes for COH, as well as the specific genetics laboratory, which includes collaborating with other departments, trouble-shooting systems common to pathology, validation and roll out processes associated with the new processes.
  • Participates in proficiency examinations per CAP guidelines and maintains a constant state of inspection readiness.
  • Perform ongoing Professional Practice Evaluation (OPPE) reports and competency review for PhD level directors and consulting staff.
  • Maintain a culture of safety and an efficient working environment.
Fiscal Oversight of Laboratory
  • Works with appropriate divisions/departments to establish and monitor all budgetary, financial and workload reporting.
  • Develops, monitors and adheres to financial plans focusing on cost benefits.
  • Projects expense levels for laboratory budgetary guidelines, monitors finances through budget review, and responds to significant variances as necessary.
  • Maintains adequate knowledge of purchasing systems, policies and procedures to negotiate optimal vendor contracts.
  • Demonstrates innovative expertise in reducing expenses in regard to both personnel and material resource management.
  • Oversees laboratory billing, as well as financial reports to ensure proper accounting and expense containment.
  • Fosters fiscal strength of the department by helping to improve efficiency and increasing revenue-producing tests.
Personnel Management
  • Establishes and develops recruitment, hiring and retention practices and policies which assure appropriate staffing.
  • Oversees supervisor scheduling and job assignments to ensure proper and timely completion of work, safety of employees, and overall efficient operation of the laboratory.
  • Reviews and provides input on performance evaluations written by supervisors, involved in disciplinary action, when needed. Participates in evaluations of laboratory staff, making recommendations for salary increases, promotion, coaching, and performance improvement.
  • Mentors supervisors and provides training to improve their leadership abilities. Oversees sectional and inter-sectional cross training of staff to increase operational efficiencies and broaden technical competency.
  • Clinical Research and Development / Translational Research Program
  • Develop and implement laboratory research and development and a translational clinical research program to remain state-of-the-art and fulfill the organizational goals and strategic plans.
Technical Direction /Oversight of Cytogenetics Shared Resources Core Facility
  • Provide cytogenetic assays and services for cancer center scientists (COH and BRI investigators) as indicated for government funded projects or clinical trials, as well as to outside researchers and investigators needing specialized cytogenetic services.
  • Design genetic studies to meet the objectives of the COH scientist, determine resources and cost, conduct tests with appropriate controls and provide an interpretation of the results.


Qualifications
Basic education, experience and skills required for consideration:
  • M.D. or Ph.D. with postdoctoral clinical fellowship training in Clinical Cytogenetics or Laboratory Genetics and Genomics.
  • Clinical cytogeneticist, preferably with previous experience as a Director of a full-service Cytogenetics laboratory, and a minimum of five years of experience as a Director of Clinical Cancer Cytogenetics.
  • Excellent interpersonal and management skills, including proven management, presentation, negotiation, team facilitation, and written communication.
  • Thorough knowledge of ISCN guidelines for conventional and molecular cytogenetics nomenclature and excellent detail-oriented work habits.
  • Thorough knowledge of State, CAP, Joint Commission, and institutional policies and procedures for directing a clinical laboratory.
  • Possess knowledge of institutional and regulatory policies, technical procedures, project and time management aspects of new test development and validation, and institutional cancer center best practices.
  • Must have ability to provide objective input on operational issues, be able to lead or facilitate large, complex, multidisciplinary projects, and have an understanding of a broad set of problem-solving methods.
  • Must be able to interact with a variety of personnel at various levels within and outside City of Hope.
Required Certification/Licensure:
  • Must be currently boarded by American Board of Medical Genetics and Genomics (ABMGG) in Clinical Cytogenetics or Laboratory Genetics and Genomics (LGG).
  • Must hold a State of California Clinical Cytogeneticist (CCG) license in good standing, or be eligible to obtain CCG. If from out of state and currently not holding CCG license, must apply for it and obtain within 24 months of hire, and must obtain Clinical Cytogenetics Scientist (CCGS) license within 3 months of hire.


City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.
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City of Hope is a leading nonprofit clinical research center—fighting major life-threatening diseases and delivering hope with exceptional treatment, prevention, and educational programs.

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