Assistant Research Professor - Precision Oncology of Gastrointestinal Cancers

    • Duarte, CA

About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy. Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary
An Assistant Research Professor (ARP) position is available in Beckman Research Institute of City of Hope. The Assistant Research Professor series is a faculty position designed for research professionals with a solid track record of research achievements in the field of translational oncology, preferably gastrointestinal (Gi) oncology. The candidate in this role is expected to have relevant research experience, a productive track record of first or senior author publications in high impact journals and mentoring experience for post-doctoral fellows and other staff in a research laboratory. The primary function of an ARP will be to support the research infrastructure and activities of the institution by utilizing the specialized research skills, knowledge and experience to research programs or institutional core laboratories. Individuals appointed as ARP will receive a one-year fixed-term contract.

This candidate will become a part of the multidisciplinary research team headed by Dr. Ajay Goel, Professor and Chair, Department of Molecular Diagnostics and Experimental Therapeutics. Our research group comprises of basic biologists, gastroenterologists, surgeons, medical oncologists and bioinformaticians, undertaking a number of collaborative projects involving large international consortia. Our research is focused on translational research as it relates to genomic and epigenomic characterization of various gastrointestinal cancers (GI) including colorectal, pancreatic and gastric cancers, and some of the key research topics include:

  • Development of circulating DNA/RNA-based liquid biopsy biomarkers for cancer diagnosis, prognosis and predictive response to various therapies.
  • Study the epigenetic basis of GI cancers (e.g. aberrant DNA methylation, histone modifications and non-coding RNAs.
  • The genetic basis of early-onset and familial/hereditary colorectal cancers.
  • The role of tumor microenvironment, stem cells, immune regulation and identification of novel targeted therapies.
  • The role of extracellular vesicles/exosomes as in cancer pathogenesis and their role as disease biomarkers. Our group performs cutting-edge research in GI oncology, is very productive and publishes in high-impact journals such as Gastroenterology, Cancer Cell, PNAS, JNCI, Clinical Cancer Research, Nature Communications, Nature Reviews Gastroenterology and Hepatology, Annals of Surgery etc.

  • Key Responsibilities include:
    • Devise, plan, document and advance basic science and translational projects in the relevant research area.
    • Generate data for grant applications and prepare manuscripts for publication.
    • Work in close collaboration with the PI and other team members and external collaborators, including presentation of progress internally or externally.
    • Train and supervise multiple post-doctoral fellows and technical staff.


    Qualifications
    Basic education, experience and skills required for consideration:
    • PhD and/or MD/PhD
    • Evidence of first or senior author peer-reviewed publications
    • Prior molecular, cancer biology and/or translational research experience and evidence of project development
    • Prior evidence for any obtaining any grant funding and plans for seeking extramural grant funding within 1-3 years of joining.

    Additional Information:
    • You will have the unique possibility to drive research towards a novel cancer diagnostics and therapeutics at the interface of science and translation to the clinic and publish high-impact journals. City of Hope offers a competitive salary, along with institutional medical insurance and other benefits, including generous institution sponsored retirement benefits for this position.
    • Please submit your current CV/resume along with a cover letter highlighting your research accomplishments, a brief statement explaining how your past research ties in with the goals of our laboratory, and future career plans.
    • For more information about the groundbreaking research taking place in the Ajay Goel, Ph.D lab, please visit www.cityofhope.org/mdet .

    City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.
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