Bristol Myers Squibb

Senior Principal Scientist

1 month agoPrinceton, NJ

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

We are seeking a highly motivated bioinformatician with preclinical or clinical experience to join our Translational Bioinformatics late stage Immunology, Cardiovascular and Fibrosis (ICF) team, within Informatics and Predictive Sciences group. The successful candidate will help advance Bristol-Myers Squibb's industry leading ICF late stage clinical programs through the strategic application of cutting edge bioinformatics approaches.

Responsibilities

Analyze various -omic-scale data generated from human subjects in BMS clinical trials and other observational cohorts including RNA-Seq, Exome and Whole Genome Sequencing, high throughput proteomics, and multiplex flow cytometry in order to validate pharmacodynamics effects, confirm mechanism of action, and enable patient enrichment strategies.

Integrate and mine large-scale external data sets to further our understanding of ICF diseases and patient treatment options.

Extract insights and generate hypotheses to be evaluated in future trials and to inform our discovery pipeline.

Collaborate with bioinformaticians, statisticians, biologists, biomarker leads, and clinicians to design experiments. Define and implement statistical/computational analysis plans.

Qualifications:

  • Ph.D. in bioinformatics, engineering, statistics, physics, molecular biology, genetics, or a similar discipline.
  • 10 or more years relevant experience in preclinical or clinical research, preferred.
  • Proven track record of independent research under minimal supervision.
  • Experience designing complex experiments and statistical analysis plans.
  • Strong background in -omic (DNA, RNA, epigenetic, proteomic) data analysis and biological interpretation.
  • Working knowledge of commercial and publicly available biological databases including NCBI, Ensembl, ArrayExpress/GEO and SRA is expected.
  • Solid background in Immunoscience, fibrosis or cardiovascular diseases preferred.
  • Strong problem-solving and collaboration skills, rigorous and creative thinking
  • Ability to communicate effectively with biologists, biostatisticians and computational scientists.
  • Proficiency using R and Bioconductor packages is preferred.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.