At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
Translational Research is part of the Research and Early Development organization at Bristol-Myers Squibb and leads early stage clinical, pharmacological and translational research and development activities for the immuno-oncology and cellular therapy pipeline and supports the late stage portfolio for regulatory, translational development and life cycle management of cellular therapies. Translational Development is in the process of organizing a late translational group to support multiple disease areas of interest including multiple myeloma, lymphoma, CLL and other hematological malignancies. This group will integrate scientific and business insights of multiple functions and lead the development and execution of translational strategies as well as hold accountability of the use and presentation of translational data in global regulatory submissions and health authority interactions to maximize the potential of BMS cellular therapies.
The successful candidate will have responsibility for leading the scientific aspects of clinical drug development programs through translational research and correlative studies in cellular therapy. The candidate will be part of the translational group based in Seattle, WA and will manage clinical studies and execute translational strategies in multiple myeloma, lymphoma and CLL for approval or life-cycle management. Key responsibilities of this role are to manage execution of translational and correlative strategies with translational scientists, computational biology, and cross-functional disease teams, in addition to contributing to strategies and activities related to health authority submission activities.
Responsibilities and Expectations:
- In-depth knowledge of fundamentals of immunology, immune oncology, and tumor biology in solid and hematological malignancies
- Utilization of translational based approaches to develop new concepts and mechanism of action hypotheses identifying distinguishing characteristic of BMS compounds alone and in combination with other therapies
- Knowledge of biomarker discovery and development: assay development/validation, clinical discovery of biomarkers, MoA research, knowledge of platforms
- Oversight and management of CROs and academic collaborators
- Manage internal projects in cell therapy drug development, including cross-functional collaborations with translational and clinical leads in multiple therapeutic and research areas
- Critically analyze, interpret, report experimental results; draw appropriate conclusions and design next steps
- Serve on internal project teams and committees as scientific functional lead
- Communicate regularly and prepare and make presentations within the department, externally, and to internal governance committees as required.
- Contribute to the writing of investigator brochures, IND applications, clinical protocols, regulatory annual reports, and other regulatory documents when appropriate
- Support regulatory submissions, regulatory interactions, write/review translational sections for regulatory response and answer to regulatory queries
- PhD or MD with at least 8 years of relevant work experience, including a minimum of 5 years of experience in clinical drug development in an industry setting and experience with regulatory filings
- Strong background in clinical biomarker discovery and analysis, research tools, platforms and assays with strong knowledge in immunology, tumor biology, and hematologic malignancies desired
- Excellent communication and interpersonal skills evidenced by strong ability to interact with research scientists, project teams, outside collaborators and commercial vendors
- Ability to work effectively and collaboratively in a highly matrixed organization
- Competence in analysis and solving of problems, and the ability to prioritize and make tradeoffs to achieve goals
- Strong written communication capabilities with experience in developing documents such as primary manuscripts/publications/reviews, disease strategies, regulatory submissions, strategic communications
- Proven scientific/project leadership expertise (working in teams, managing collaborations, people/projects)
- Detail-oriented with the ability to identify and implement creative solutions
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.
Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to email@example.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
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